2-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-acetamide

Base Information

• Chemical Name: 2-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-acetamide
• CAS No.: 626605-07-0
• Molecular Formula: C₂₈H₃₃N₃O₂Si
• Molecular Weight: 471.674
• Mol file: 626605-07-0.mol

Synonyms:2-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-acetamide

Chemical Property of 2-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-acetamide

There total 3 articles about 2-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-(tert-butyldimethylsilyloxy)propyl bromide (89031-84-5) + 2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acetamide (626605-06-9) → 2-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-acetamide (626605-07-0)

Guidance literature:

With caesium carbonate; In DMF (N,N-dimethyl-formamide); at 70 ℃; for 6h;

Reference yield: 60.0%

3-(tert-butyldiphenylsilyloxy)propyl bromide (177338-13-5) + 2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acetamide (626605-06-9) → 2-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-acetamide (626605-07-0)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 6h;

DOI:10.1016/j.bmc.2004.04.010

Reference yield:

1H-Pyrrolo[2,3-b]pyridin-3-yl-acetonitrile (4414-87-3) → 2-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-acetamide (626605-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / H₂O₂; K₂CO₃ / H₂O; dimethylsulfoxide / 0.17 h

2: 60 percent / Cs₂CO₃ / dimethylformamide / 6 h / 70 °C

With dihydrogen peroxide; potassium carbonate; caesium carbonate; In water; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2004.04.010

upstream raw materials:

3-(tert-butyldiphenylsilyloxy)propyl bromide

2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acetamide

1H-Pyrrolo[2,3-b]pyridin-3-yl-acetonitrile

3-(tert-butyldimethylsilyloxy)propyl bromide

Downstream raw materials:

3-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-4-hydroxy-pyrrole-2,5-dione

4-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-1'-triisopropylsilanyl-1'H-[3,3']bipyrrolyl-2,5-dione

3-{1-[3-(tert-butyldiphenylsilanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-4-dibenzofuran-4-yl-pyrrole-2,5-dione

3-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-4-(4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyridin-2-yl)-pyrrole-2,5-dione