6-bromoimidazo[1,2-a]pyrazin-3-amine

Base Information

• Chemical Name: 6-bromoimidazo[1,2-a]pyrazin-3-amine
• CAS No.: 767342-46-1
• Molecular Formula: C6H5BrN4
• Molecular Weight: 213.037
• Mol file: 767342-46-1.mol

Synonyms:6-bromoimidazo[1,2-a]pyrazin-3-amine;6-Bromo-imidazo[1,2-a]pyrazin-3-ylamine

Chemical Property of 6-bromoimidazo[1,2-a]pyrazin-3-amine

Chemical Property:

• PSA: 56.21000
• LogP: 1.65520

Purity/Quality:

6-Bromo-imidazo[1,2-a]pyrazin-3-ylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-bromoimidazo[1,2-a]pyrazin-3-amine

There total 1 articles about 6-bromoimidazo[1,2-a]pyrazin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-(5-bromo-pyrazin-2-yl)-N-cyanomethyl-4-methyl-benzenesulfonamide (767342-44-9) → 6-bromo-imidazo[1,2-a]pyrazin-3-ylamine (767342-46-1)

Guidance literature:

N-(5-bromo-pyrazin-2-yl)-N-cyanomethyl-4-methyl-benzenesulfonamide; With trifluoroacetic acid; In water; at 40 ℃; for 1h;

With sodium acetate; In water; at 0 ℃; for 1h;

Reference yield: 79.0%

6-bromo-imidazo[1,2-a]pyrazin-3-ylamine (767342-46-1) + o-methylphenylacetic acid (644-36-0) → N-(6-bromo-imidazo[1,2-a]pyrazin-3-yl)-2-methyl-benzamide

Guidance literature:

o-methylphenylacetic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 3h;

6-bromo-imidazo[1,2-a]pyrazin-3-ylamine; In tetrahydrofuran; pyridine; at 50 ℃; for 0.5h;

Reference yield:

6-bromo-imidazo[1,2-a]pyrazin-3-ylamine (767342-46-1) + (o-tolyl)acetyl chloride (10166-09-3) → C15H13BrN4O

Guidance literature:

6-bromo-imidazo[1,2-a]pyrazin-3-ylamine; (o-tolyl)acetyl chloride; With pyridine; In tetrahydrofuran; at 50 ℃; for 0.5h;

With sodium hydrogencarbonate; In water; ethyl acetate;

upstream raw materials:

N-(5-bromo-pyrazin-2-yl)-N-cyanomethyl-4-methyl-benzenesulfonamide