5-(2-Pyridyl)-1,2-dihydropyridin-2-one

Base Information

• Chemical Name: 5-(2-Pyridyl)-1,2-dihydropyridin-2-one
• CAS No.: 381233-78-9
• Molecular Formula: C10H8N2O
• Molecular Weight: 172.186
• Hs Code.: 2933399090
• European Community (EC) Number: 691-966-8
• DSSTox Substance ID: DTXSID80437133
• Nikkaji Number: J2.329.734E
• Mol file: 381233-78-9.mol

Synonyms:381233-78-9;[2,3'-Bipyridin]-6'(1'H)-one;5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE;5-pyridin-2-yl-1H-pyridin-2-one;5-(2-Pyridyl)pyridin-2(1H)-one;5-(pyridin-2-yl)-1,2-dihydropyridin-2-one;5-(PYRIDIN-2-YL)PYRIDIN-2(1H)-ONE;MFCD11113414;5-(Pyridin-2-yl)-2(1H)-pyridone;2,3'-bipyridin-6'-one;SCHEMBL688244;DTXSID80437133;NHWKTZWOSIVHOL-UHFFFAOYSA-N;2-Hydroxy-5-(2-pyridyl)pyridine;5-(2-Pyridyl)-2(1H)-pyridone;5-Pyridin-2-yl-2(1H)-pyridone;AMY19981;BCP09881;5-Pyridin-2-yl-2 (1H)-pyridone;AKOS006281920;AKOS015945703;CH-0026;AC-27376;SY033084;FT-0696698;1',6'-dihydro-[2,3'-bipyridine]-6'-one;EN300-76678;A851933;Z1190318468

Chemical Property of 5-(2-Pyridyl)-1,2-dihydropyridin-2-one

Chemical Property:

• Boiling Point: 434.3±45.0 °C(Predicted)
• PKA: 10.85±0.10(Predicted)
• PSA: 45.75000
• Density: 1.221±0.06 g/cm3 (20 ºC 760 Torr)
• LogP: 1.43690
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 172.063662883
• Heavy Atom Count: 13
• Complexity: 268

Purity/Quality:

97% ^*data from raw suppliers

[2,3'-Bipyridin]-6'(1'H)-one 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C2=CNC(=O)C=C2
• Uses: 5-(2-Pyridyl)-1,2-dihydropyridin-2-one is used in the synthesis of AMPA receptor antagonists in the treatment of neurological diseases causing dysfunction of glutamatergic neurotransmission.

Technology Process of 5-(2-Pyridyl)-1,2-dihydropyridin-2-one

There total 18 articles about 5-(2-Pyridyl)-1,2-dihydropyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.9%

2-methoxy-5-(pyridin-2-yl)pyridine (381725-49-1) → 5-(2-Pyridyl)-1,2-dihydropyridin-2-one (381233-78-9)

Guidance literature:

With water; at 95 - 100 ℃; for 4h; Acidic conditions;

Reference yield: 70.0%

2-bromo-pyridine (109-04-6) + 2-hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1054483-78-1) → 5-(2-Pyridyl)-1,2-dihydropyridin-2-one (381233-78-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; acetonitrile; at 75 ℃;

DOI:10.1016/j.bmcl.2011.08.009

Reference yield: 69.0%

→ 5-(2-Pyridyl)-1,2-dihydropyridin-2-one (381233-78-9)

Guidance literature:

upstream raw materials:

2-methoxy-5-(pyridin-2-yl)pyridine

butan-1-ol

2-chloro-5-(2'-pyridyl)pyridine

1-(6-hydroxypyridin-3-yl)ethanone

Downstream raw materials:

1-phenyl-5-(pyridin-2-yl)-2(1H)-pyridone

C₁₈H₁₆N₂S

3-bromo-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridine-2-one

[14C]-Perampanel