5-Bromo-6-methyl-3-nitropyridin-2-ol

Base Information

Chemical Name:5-Bromo-6-methyl-3-nitropyridin-2-ol
CAS No.:186413-74-1
Molecular Formula:C6H5BrN2O3
Molecular Weight:233.0195
Hs Code.:2933399090
DSSTox Substance ID:DTXSID00442800
Wikidata:Q82260301
Mol file:186413-74-1.mol

Synonyms:186413-74-1;5-Bromo-6-methyl-3-nitropyridin-2-ol;5-Bromo-2-hydroxy-3-nitro-6-picoline;5-Bromo-2-hydroxy-6-methyl-3-nitropyridine;5-bromo-6-methyl-3-nitro-1H-pyridin-2-one;5-Bromo-6-methyl-3-nitropyridin-2(1H)-one;5-BROMO-3-NITRO-6-METHYLPYRIDIN-2(1H)-ONE;2(1H)-Pyridinone, 5-bromo-6-methyl-3-nitro-;SCHEMBL16321777;DTXSID00442800;OEBQKJOFOWLDME-UHFFFAOYSA-N;AMY28761;MFCD09839284;MFCD11973727;3-nitro-5-bromo-6-methyl-2-pyridone;AKOS016005581;GS-5042;SB21115;SY019552;CS-0091644;FT-0736429;P11282;EN300-1087016;A880658;5-bromo-6-methyl-3-nitro-1,2-dihydropyridin-2-one;5-broMo-6-Methyl-3-nitropyridin-2-ol

Suppliers and Price of 5-Bromo-6-methyl-3-nitropyridin-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Bromo-2-hydroxy-3-nitro-6-picoline
500mg
$ 65.00

TRC
5-Bromo-2-hydroxy-3-nitro-6-picoline
100mg
$ 45.00

Crysdot
5-Bromo-6-methyl-3-nitropyridin-2-ol 97%
25g
$ 608.00

Crysdot
5-Bromo-6-methyl-3-nitropyridin-2-ol 97%
10g
$ 337.00

Chemenu
5-Bromo-6-methyl-3-nitropyridin-2-ol 97%
10g
$ 315.00

Chemenu
5-Bromo-6-methyl-3-nitropyridin-2-ol 97%
25g
$ 568.00

Chemcia Scientific
5-Bromo-6-methyl-3-nitro-1H-pyridin-2-one ＞95%
5 G
$ 225.00

American Custom Chemicals Corporation
5-BROMO-3-NITRO-6-METHYLPYRIDIN-2(1H)-ONE 95.00%
1G
$ 883.05

American Custom Chemicals Corporation
5-BROMO-3-NITRO-6-METHYLPYRIDIN-2(1H)-ONE 95.00%
5MG
$ 500.84

Ambeed
5-Bromo-2-hydroxy-6-methyl-3-nitropyridine 98%
250mg
$ 44.00

Total 19 raw suppliers

Chemical Property of 5-Bromo-6-methyl-3-nitropyridin-2-ol

Chemical Property:

PSA：78.94000
LogP:2.28950
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:231.94835
Heavy Atom Count:12
Complexity:313

Purity/Quality:

99%, ^*data from raw suppliers

5-Bromo-2-hydroxy-3-nitro-6-picoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 20/22
Safety Statements: 36/37

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=C(C(=O)N1)[N+](=O)[O-])Br

Technology Process of 5-Bromo-6-methyl-3-nitropyridin-2-ol

There total 1 articles about 5-Bromo-6-methyl-3-nitropyridin-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 68957-50-6
2-amino-5-bromo-6-methyl-3-nitropyridine

: 186413-74-1
5-Bromo-6-methyl-3-nitro-1H-pyridin-2-one

Guidance literature:: With sulfuric acid; sodium nitrite; at 0 ℃; for 0.5h;
DOI:10.1002/jhet.5570330670

Reference yield: 75.0%

: 186413-74-1
5-Bromo-6-methyl-3-nitro-1H-pyridin-2-one

: 186413-75-2
3-bromo-6-chloro-2-methyl-5-nitropyridine

Guidance literature:: With pyridine; trichlorophosphate; In chlorobenzene; for 1h; Heating;
DOI:10.1002/jhet.5570330670

Reference yield:

: 186413-74-1
5-Bromo-6-methyl-3-nitro-1H-pyridin-2-one

: Diethyl-carbamic acid 6-[3-(2,2-dimethyl-propionylamino)-6-methyl-2-quinolin-2-yl-pyridin-4-yl]-2,3-dimethoxy-phenyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 75 percent / POCl₃, pyridine / chlorobenzene / 1 h / Heating

2: 90 percent / Et₃N / 144 h / Heating

3: 95 percent / H₂ / 10percent Pd/C / ethanol / 760 Torr

4: 95 percent / Et₃N / diethyl ether / 1 h / Ambient temperature

5: 1.) n-BuLi, tetramethylethylenediamine, 2.) I₂ / 1.) THF, hexane, a) -78 deg C, 15 min, b) -25 deg C, 45 min, 2.) THF, hexane, a) -78 deg C, 15 min, b) -25 deg C, 3 h

6: 80 percent / BBr₃ / CH₂Cl₂ / 10 h / Ambient temperature

7: 91 percent / pyridine / 25 h / Ambient temperature

8: 85 percent / K₂CO₃, Pd(PPh₃)4 / toluene; ethanol / 2 h / 110 °C

9: 45 percent / LiCl, CuBr₂, Pd(PPh₃)4 / dioxane / 48 h / Heating

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen; iodine; boron tribromide; potassium carbonate; triethylamine; lithium chloride; copper(ll) bromide; trichlorophosphate; palladium on activated charcoal; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; chlorobenzene; toluene;
DOI:10.1002/jhet.5570330670