Artemisinin-d3

Base Information

Chemical Name:Artemisinin-d3
CAS No.:176652-07-6
Molecular Formula:C15H19D3O5
Molecular Weight:285.3507
Hs Code.:
DSSTox Substance ID:DTXSID90444833
Wikidata:Q82263107
Mol file:176652-07-6.mol

Synonyms:Artemisinin-d3;176652-07-6;(1R,4S,5R,8S,9R,12S,13R)-1,5-dimethyl-9-(trideuteriomethyl)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one;3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6-dimethyl-9-(methyl-d3)-, [3R-(3alpha,5abeta,6beta,8abeta,9alpha,12beta,12aR*)]- (9CI);HY-B0094S;DTXSID90444833;AKOS030241611;CS-0092170;J-011209;(1R,4S,5R,8S,9R,12S,13R)-9-(?H?)methyl-1,5-dimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0?,??.0?,??]hexadecan-10-one

Suppliers and Price of Artemisinin-d3

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Artemisinin-d3
1mg
$ 566.00

TRC
Artemisinin-d3
10mg
$ 2180.00

Cayman Chemical
Artemisinin-d3 ≥99% deuterated forms (d1-d3)
1mg
$ 399.00

American Custom Chemicals Corporation
ARTEMISININ-D3 95.00%
5MG
$ 501.36

aablocks
3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one,octahydro-3,6-dimethyl-9-(methyl-d3)-,[3R-(3α,5aβ,6β,8aβ,9α,12β,12aR*)]-(9CI) ≥99%deuteratedforms(d1-d3)
5mg
$ 2038.00

Total 10 raw suppliers

Chemical Property of Artemisinin-d3

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:156-157°C
Boiling Point:389.899°C at 760 mmHg
Flash Point:171.953°C
PSA：53.99000
Density:1.26g/cm³
LogP:2.39490
Storage Temp.:-20°C Freezer
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:285.16555404
Heavy Atom Count:20
Complexity:452

Purity/Quality:

99% ^*data from raw suppliers

Artemisinin-d3 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1CCC2C(C(=O)OC3C24C1CCC(O3)(OO4)C)C
Isomeric SMILES:[2H]C([2H])([2H])[C@@H]1[C@@H]2CC[C@H]([C@H]3[C@]24[C@H](OC1=O)O[C@@](CC3)(OO4)C)C
Description Artemisinin-d3 is intended for use as an internal standard for the quantification of artemisinin . Artemisinin is an endoperoxide antimalarial agent with anticancer activity. It reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM) and reduces parasitemia in mice infected with P. falciparum with a curative dose (CD50) value of 140 mg/kg. It also reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day). Artemisinin (100-400 μM) induces cell cycle arrest in the G0/G1 phase and apoptosis and inhibits growth of SK-N-AS, BE(2)-C, SK-N-DZ, and SHEP1 neuroblastoma cells in a time- and concentration-dependent manner. It also suppresses BE(2)-C cell colony formation in a soft agar assay and reduces tumor growth in a BE(2)-C mouse xenograft model. Formulations containing artemisinin have been used in combination therapies for the treatment of malaria.
Uses Active antimalarial constituent of the tradional Chinese medicinal herb Artemisia annua L., Compositae, which has been known for almost 2000 years as Qinghao. Antimalarial

Technology Process of Artemisinin-d3

There total 2 articles about Artemisinin-d3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 176652-10-1
2,5,5-trimethyl-2-<2'-<4''-(1(S)-carboxy-2-2H3-ethyl)-1''(R)-methyl-3''-<(trimethylsilyl)methylene>cyclohex-2''-yl>ethyl>-1,3-dioxane

: 176652-07-6
artemisinin-d3

Guidance literature:: With sulfuric acid; silica gel; ozone; Yield given. Multistep reaction; 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, RT, 3 d;
DOI:10.1002/(SICI)1099-1344(199603)38:3<249::AID-JLCR840>3.0.CO;2-D

Reference yield:

: 116399-92-9
2,5,5-trimethyl-2-<2'-<4''-(carboxymethyl)-1''(R)-methyl-3''-<(trimethylsilyl)methylene>cyclohex-2''-yl>ethyl>-1,3-dioxane

: 176652-07-6
artemisinin-d3

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, hexane, a.) from -78 deg C to RT, 30 min, b) 50 deg C, 2 h, 2.) THF, hexane, RT, 1 h

2: 1.) O₃, 2.) 15percent aq. H₂SO₄, silica gel / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, RT, 3 d

With sulfuric acid; silica gel; ozone; lithium diisopropyl amide;
DOI:10.1002/(SICI)1099-1344(199603)38:3<249::AID-JLCR840>3.0.CO;2-D

Reference yield: 75.0%

: 176652-07-6
artemisinin-d3

: 176774-98-4
dihydroartemisinin-d3

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 2h;
DOI:10.1002/(SICI)1099-1344(199603)38:3<249::AID-JLCR840>3.0.CO;2-D