4-(2-chloroisonicotinoyl)morpholine

Base Information

• Chemical Name: 4-(2-chloroisonicotinoyl)morpholine
• CAS No.: 174482-98-5
• Molecular Formula: C10H11ClN2O2
• Molecular Weight: 226.66
• Hs Code.: 2934999090
• Mol file: 174482-98-5.mol

Synonyms:Albb-004238;

Chemical Property of 4-(2-chloroisonicotinoyl)morpholine

Chemical Property:

• Vapor Pressure: 4.41E-07mmHg at 25°C
• Boiling Point: 414.6°C at 760 mmHg
• Flash Point: 204.5°C
• PSA: 42.43000
• Density: 1.327g/cm³
• LogP: 1.14530
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-(2-Chloroisonicotinoyl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-chloroisonicotinoyl)morpholine

There total 3 articles about 4-(2-chloroisonicotinoyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

4-morpholinocarbonyl chloride (15159-40-7) + 2-chloro-4-pyridylzinc bromide (1227940-97-7) → (2-chloropyridin-4-yl)(morpholino)methanone (174482-98-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.5012/bkcs.2013.34.5.1575

Reference yield:

morpholine (110-91-8,99108-56-2) + 2-chloroisonicotinic acid, (6313-54-8) → (2-chloropyridin-4-yl)(morpholino)methanone (174482-98-5)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 20 ℃; for 24h;

Reference yield:

2-chloro-4-bromopyridine (73583-37-6) → (2-chloropyridin-4-yl)(morpholino)methanone (174482-98-5)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc; lithium chloride / 2 h / 20 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 24 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; lithium chloride; zinc; In tetrahydrofuran;

DOI:10.5012/bkcs.2013.34.5.1575

upstream raw materials:

morpholine

2-chloroisonicotinic acid,

4-morpholinocarbonyl chloride

2-chloro-4-pyridylzinc bromide

Refernces

• 1、 -. "SUBSTITUTED 2H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS GSK-3 INHIBITORS". Page/Page column 31. . Retrieved 2010/02/11.