1-Benzyl-3-hydroxyimino-2-methylpyrrolidine

Base Information

• Chemical Name: 1-Benzyl-3-hydroxyimino-2-methylpyrrolidine
• CAS No.: 74880-17-4
• Molecular Formula: C12H16N2O
• Molecular Weight: 204.27
• Hs Code.: 2933990090
• Mol file: 74880-17-4.mol

Synonyms:2-Methyl-1-(phenylmethyl)-3-pyrrolidinone Oxim;

Chemical Property of 1-Benzyl-3-hydroxyimino-2-methylpyrrolidine

Chemical Property:

• PSA: 35.83000
• LogP: 2.04890

Purity/Quality:

99% ^*data from raw suppliers

1-Benzyl-3-hydroxyimino-2-methylpyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A benzamide derivative

Technology Process of 1-Benzyl-3-hydroxyimino-2-methylpyrrolidine

There total 1 articles about 1-Benzyl-3-hydroxyimino-2-methylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(α-ethoxycarbonylethyl)-β-ethoxycarbonylethylbenzylamine (60584-77-2) → 1-benzyl-3-(hydroxyimino)-2-methylpyrrolidine (74880-17-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / hydroxylamine hydrochloride; KOH / ethanol / Heating

With potassium hydroxide; hydroxylamine hydrochloride; In ethanol; 1: Dieckmann cyclization;

DOI:10.1023/B:COHC.0000028629.93231.b8

Reference yield:

1-benzyl-3-(hydroxyimino)-2-methylpyrrolidine (74880-17-4) → cis-3-amino-1-benzyl-2-methylpyrrolidine (70325-82-5,74880-18-5,78775-36-7,93664-91-6) + trans-3-amino-1-benzyl-2-methylpyrrolidine (70325-82-5,74880-18-5,78775-36-7,93664-91-6)

Guidance literature:

With ammonium hydroxide; hydrogen; nickel; In methanol; ethanol; at 5 ℃;

DOI:10.1021/jm00142a019

Reference yield:

1-benzyl-3-(hydroxyimino)-2-methylpyrrolidine (74880-17-4) → N-((2S,3R)-1-Benzyl-2-methyl-pyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylamino-benzamide (70325-83-6,75272-39-8)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, aq. ammonia / Raney nickel / methanol; ethanol / 5 °C

2: CH₂Cl₂ / 2 h / Ambient temperature

With ammonium hydroxide; hydrogen; nickel; In methanol; ethanol; dichloromethane;

DOI:10.1021/jm00142a019

upstream raw materials:

(α-ethoxycarbonylethyl)-β-ethoxycarbonylethylbenzylamine

Downstream raw materials:

cis-3-amino-1-benzyl-2-methylpyrrolidine

trans-3-amino-1-benzyl-2-methylpyrrolidine

N-((2S,3R)-1-Benzyl-2-methyl-pyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylamino-benzamide

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