n-(1-Benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide

Base Information

Chemical Name:n-(1-Benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide
CAS No.:70325-83-6
Molecular Formula:C₂₁H₂₆ClN₃O₂
Molecular Weight:387.909
Hs Code.:
DSSTox Substance ID:DTXSID90860978
Nikkaji Number:J3.035.227K
Wikipedia:Nemonapride
Wikidata:Q6991226
NCI Thesaurus Code:C73036
Pharos Ligand ID:LYHDGWL5QAJ8
ChEMBL ID:CHEMBL20734
Mol file:70325-83-6.mol

Synonyms:cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide;emonapride;nemonapride;nemonapride, (cis)-isomer;YM 09151-2;YM 09151-M;YM-09151-2

Suppliers and Price of n-(1-Benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of n-(1-Benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide

Chemical Property:

Vapor Pressure:1.03E-10mmHg at 25°C
Boiling Point:514.9°C at 760 mmHg
Flash Point:265.2°C
PSA：53.60000
Density:1.23g/cm³
LogP:4.18490
XLogP3:3.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:387.1713548
Heavy Atom Count:27
Complexity:486

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C(CCN1CC2=CC=CC=C2)NC(=O)C3=CC(=C(C=C3OC)NC)Cl

Technology Process of n-(1-Benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide

There total 14 articles about n-(1-Benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74880-17-4
1-benzyl-3-(hydroxyimino)-2-methylpyrrolidine

: 70325-83-6,75272-39-8
N-((2S,3R)-1-Benzyl-2-methyl-pyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylamino-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂, aq. ammonia / Raney nickel / methanol; ethanol / 5 °C

2: CH₂Cl₂ / 2 h / Ambient temperature

With ammonium hydroxide; hydrogen; nickel; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm00142a019

Reference yield:

: 74880-17-4
1-benzyl-3-(hydroxyimino)-2-methylpyrrolidine

: 70325-83-6,75272-39-8
Emilace

Guidance literature:: Multi-step reaction with 2 steps

1: H₂, aq. ammonia / Raney nickel / methanol; ethanol / 5 °C

2: CH₂Cl₂ / 2 h / Ambient temperature

With ammonium hydroxide; hydrogen; nickel; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm00142a019

Reference yield:

: 61694-98-2
5-chloro-2-methoxy-4-(methylamino)benzoic acid

: 70325-83-6,75272-39-8
N-((2S,3R)-1-Benzyl-2-methyl-pyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylamino-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / 0.5 h / -40 - -10 °C

2: CH₂Cl₂ / 2 h / Ambient temperature

With triethylamine; In dichloromethane;
DOI:10.1021/jm00142a019