3-BROMO-2-METHYL-BENZENESULFONYL CHLORIDE

Base Information

• Chemical Name: 3-BROMO-2-METHYL-BENZENESULFONYL CHLORIDE
• CAS No.: 886501-61-7
• Molecular Formula: C7H6BrClO2S
• Molecular Weight: 269.546
• Hs Code.: 2904909090
• Mol file: 886501-61-7.mol

Synonyms:3-bromo-2-methylbenzenesulfonyl chloride

Chemical Property of 3-BROMO-2-METHYL-BENZENESULFONYL CHLORIDE

Chemical Property:

• Vapor Pressure: 0.000326mmHg at 25°C
• Boiling Point: 330.1ºC at 760 mmHg
• Flash Point: 153.4ºC
• PSA: 42.52000
• Density: 1.7g/cm3
• LogP: 3.76580
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-2-methyl-benzenesulfonylchloride 85% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-2-METHYL-BENZENESULFONYL CHLORIDE

There total 3 articles about 3-BROMO-2-METHYL-BENZENESULFONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

3-bromo-2-methylaniline (55289-36-6) → 3-bromo-2-methylbenzene-1-sulfonyl chloride (886501-61-7)

Guidance literature:

With hydrogenchloride; sulfur dioxide; acetic acid; copper dichloride; sodium nitrite; In water; acetonitrile; at 0 - 20 ℃; for 16h;

Reference yield:

1-benzylsulfanyl-3-bromo-2-methyl-benzene (1182728-66-0) → 3-bromo-2-methylbenzene-1-sulfonyl chloride (886501-61-7)

Guidance literature:

With sulfuryl dichloride; water; acetic acid; In dichloromethane; at 0 - 20 ℃; for 0.416667h;

Reference yield:

2,6-dibromotoluene (69321-60-4) → 3-bromo-2-methylbenzene-1-sulfonyl chloride (886501-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 100 °C / Inert atmosphere

2: sulfuryl dichloride; water; acetic acid / dichloromethane / 0.42 h / 0 - 20 °C

With sulfuryl dichloride; water; acetic acid; N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane;

upstream raw materials:

1-benzylsulfanyl-3-bromo-2-methyl-benzene

3-bromo-2-methylaniline

2,6-dibromotoluene

Downstream raw materials:

3-[1-(3-bromo-2-methyl-benzenesulfonyl)-5-fluoro-1H-indol-3-yl]-propionic acid methyl ester

5-chloro-thiophene-2-carboxylic acid [(S)-2-(3-bromo-2-methyl-benzenesulfonyl-amino)-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]-amide

C₇H₈BrNO₂S

C₁₃H₂₀BNO₄S

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