69321-60-4

Usage

Chemical Properties

Colorless liquid

Preparation

2,6-Dibromotoluene is an important pharmaceutical intermediate，It can be made from toluene using sulfonation and desulfonation as intermediate steps in the synthesis.

InChI:InChI=1/C7H6Br2/c1-5-6(8)3-2-4-7(5)9/h2-4H,1H3

Upstream product

• 13194-73-5 3,5-dibromo-4-methylaniline 
• 80948-78-3 2,4-dibromo-3-methylaniline 
• 108545-81-9 1,3-dibromo-5-tert-butyl-2-methylbenzene 
• 99-99-0 1-methyl-4-nitrobenzene 
• 90914-81-1 4-bromo-3-methylacetanilide 
• 594-27-4 tetramethylstannane 
• 1177558-44-9 (3,5-dibromo-4-methylphenyl)amine hydrochloride 
• 827-32-7 4-bromo-5-methyl-2-nitrophenylamine 
• 98840-42-7 2,6-diamino-4-t-butyltoluene 
• 4162-89-4 4-(tert-butyl)-2,6-dinitrotoluene 
• 98-51-1 4-tert-butyltoluene 
• 55289-35-5 2-bromo-6-nitrotoluene 
• 101581-06-0 1,3-dibromo-2-methyl-5-nitrobenzene 
• 55289-36-6 3-bromo-2-methylaniline 

Downstream Products

• 116779-85-2 2,3,6-tribromo-toluene 
• 67713-23-9 2,6-dibromobenzaldehyde 
• 93701-32-7 2,6-dibromobenzyl bromide 
• 110127-07-6 2,6-dibromo-3-nitro-toluene 
• 69321-59-1 (3-bromo-2-methyl-phenyl)-phenyl sulfone 
• 392318-87-5 2,6-dibromo-3,5-dinitro-toluene 
• 51689-50-0 2-methylbenzene-1,3-dicarboxaldehyde 
• 865756-45-2 2,6-bis(4-pyridylethynyl)toluene 
• 80515-60-2 2,6-dideuteriotoluene 
• 923282-14-8 [2,6-2H₂]benzyl bromide 
• 159618-36-7 2,6-Dicyanobenzaldehyde 
• 331714-62-6 2-(2,6-dibromophenyl)-1,3-dioxolane 
• 331714-63-7 2-(2,6-dicyanophenyl)-1,3-dioxolane 
• 108-36-1 1,3-dibromobenzene 

Relevant academic research and scientific papers

Through space interaction between ferrocenes mediated by a thioether

A series of conformationally constrained 2,6-bisferrocenylphenyl thioethers were synthesized via Suzuki-Miyaura cross coupling reactions. Structural information was obtained using X-ray crystallography and dynamic 1H NMR spectroscopic studies,

Dual Pharmacophores - PDE4-Muscarinic Antagonistics

The present invention relates to novel compounds of Formula (I) and their use in the treatment of respiratory diseases, including anti-inflammatory and allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis (e.g. allergic rhinitis), atopic dermatitis or psoriasis.

DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS

The present invention is directed to novel compounds of Formula's (I) - (VI), and pharmaceutically acceptable salts thereof, pharmaceutical compositions and their use in therapy, for example as inhibitors of phosphodiesterase type IV (PDE4) and as antagonists of muscarinic acetylcholine receptors (mAChRs), in the treatment of and/or prophylaxis of respiratory diseases, including inflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis (e.g. allergic rhinitis), atopic dermatitis or psoriasis.

Dual Pharmacophores - PDE4-Muscarinic Antagonistics

The present invention is directed to novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions and their use as dual chromaphores having inhibitory activity against PDE4 and muscarinic acetylcholine receptors (mAChRs), and thus being useful for treating respiratory diseases.

Dual Pharmacophores - PDE4-Muscarinic Antagonistics

The present invention is directed to novel compounds of Formula (I), pharmaceutical compositions and their use in therapy, for example as inhibitors of phosphodiesterase type IV (PDE4) and as antagonists of muscarinic acetylcholine receptors (mAChRs), in the treatment of/and or prophylaxis of respiratory diseases, including antiinflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis (e.g. allergic rhinitis), atopic dermatitis or psoriasis.

Palladium-catalyzed cross-coupling alkylation of arenediazonium o-benzenedisulfonimides

Arenediazonium o-benzenedisulfonimides were reacted with tetramethyltin, tetrabutyltin or trialkylboranes. The reactions, carried out in the presence of palladium(II) derivatives as precatalysts, gave the methylation and alkylation products with good over

Palladium-catalyzed monoamination of dihalogenated benzenes

The palladium-catalyzed monoamination of symmetric dibromobenzenes can be performed using a catalyst based on Pd2dba3 and BINAP in the presence of NaO(t-Bu). The analogous transformation of non-symmetric bromoiodobenzenes is most effectively performed with Xantphos as the ligand, while reactions with BINAP were non-selective. These transformations can be scaled uneventfully to >10 g quantities. They do not require drybox or Schlenk techniques, and all reagents are weighed out in air. The resulting monobromoanilines are versatile intermediates for further synthetic transformations.

Poly(thiaheterohelicene): A stiff conjugated helical polymer comprised of fused benzothiophene rings

(Chemical Equation Presented) A novel helical aromatic polymer comprised of fused benzothiophene rings, poly(thiaheterohelicene), was synthesized via an intramolecular ring-closing reaction with a controlled helicity to one-sided bias. The synthetic helic

Synthesis, absorption and luminescence of a new series of soluble distyrylbenzenes featuring cyano substituents at the peripheral rings

The synthesis of a complete series of nine soluble distyrylbenzenes (DSBs) with two (2a-c) and four cyano groups (1a-f) attached to the peripheral aromatic rings is reported. They were prepared by the Wittig reaction and characterized by 1H and 13C NMR, FT-IR, UV/Vis, PL, EL, mass spectra, and elemental analysis. The optical properties have been studied in detail to monitor structure-luminescence relationships as a function of the position of the cyano moieties. The DSBs with cyano substituents show bathochromic shifts in their absorption spectra when compared to the parent DSB (30). The extent of this red-shift depends on electronic and steric factors. The bis(p-cyano)-substituted compound 2c exhibits a small Stokes shift and a remarkably high quantum yield of ψF = 0.6-0.8 in the solid state. All the new distyrylbenzenes show electroluminescence when employed in devices with an ITO/PcCu/DSB/Al configuration and with colors ranging from red to green.

Metacyclophanes and Related Compounds. Part 16. Preparation of 8-Fluoro-t-butylmetacyclophanes and their Treatment with Aluminium Chloride-Nitromethane in Benzene

The preparation of 8-fluoro-t-butylmetacyclophanes (5) are described.Dithiametacyclophane (3) and metacyclophane bis(sulphones) (4) were obtained as a mixture of transoid and cisoid conformers, but metacyclophanes (5) were exclusively obtained as the transoid conformer after pyrolysis of the sulphones (4).AlCl3-MeNO2-Catalyzed trans-t-butylation of 8-fluoro-16-methyl-5,13-di-t-butylmetacyclophane (5a) in benzene under a variety of conditions faild to give 8-fluoro-16-methylmetacyclophane (32) but, instead, the tetrahydropyrenes (33) and/or (34) were obtained depending upon the conditions used.Internally substituted metacyclophanes were isomerized to the strainless metacyclophanes and these were then oxidized to the tetrahydropyrene (33).