2-Amino-5-ureido-4,6-pyrimidinedione

Base Information

• Chemical Name: 2-Amino-5-ureido-4,6-pyrimidinedione
• CAS No.: 21823-25-6
• Molecular Formula: C5H7N5O3
• Molecular Weight: 185.142
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID50401987
• Mol file: 21823-25-6.mol

Synonyms:2-AMINO-5-UREIDO-4,6-PYRIMIDINEDIONE;21823-25-6;(2-amino-4,6-dioxo-1H-pyrimidin-5-yl)urea;(2-amino-4,6-dioxo-1,4,5,6-tetrahydropyrimidin-5-yl)urea;SCHEMBL12959117;DTXSID50401987;AKOS006292651;J-014305

Chemical Property of 2-Amino-5-ureido-4,6-pyrimidinedione

Chemical Property:

• Melting Point: >400°C
• PSA: 145.14000
• Density: 2.2 g/cm³
• LogP: -1.23970
• Storage Temp.: -20°C Freezer
• Solubility.: Aqueous Base (Slightly), Water
• XLogP3: -2.6
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 185.05488910
• Heavy Atom Count: 13
• Complexity: 309

Purity/Quality:

98%Min ^*data from raw suppliers

2-Amino-5-ureido-4,6-pyrimidinedione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1(C(=O)NC(=NC1=O)N)NC(=O)N

Technology Process of 2-Amino-5-ureido-4,6-pyrimidinedione

There total 3 articles about 2-Amino-5-ureido-4,6-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ureido-malonic acid diethyl ester (500880-58-0) + guanidine hydrochloride (50-01-1) → (2-amino-4,6-dioxo-1,4,5,6-tetrahydro-pyrimidin-5-yl)-urea (21823-25-6)

Guidance literature:

ureido-malonic acid diethyl ester; guanidine hydrochloride; With sodium methylate; In methanol; Inert atmosphere; Reflux;

With hydrogenchloride; In water; at 5 ℃; for 0.5h;

Reference yield:

→ (2-amino-4,6-dioxo-1,4,5,6-tetrahydro-pyrimidin-5-yl)-urea (21823-25-6)

Guidance literature:

Reference yield:

→ (2-amino-4,6-dioxo-1,4,5,6-tetrahydro-pyrimidin-5-yl)-urea (21823-25-6)

Guidance literature:

entspr. Ureidomalonat, Guanidin;

DOI:10.1021/jo00828a062

upstream raw materials:

ureido-malonic acid diethyl ester

guanidine hydrochloride

Downstream raw materials:

8-oxo-7,8-dihydroguanine

Refernces