Atorvastatin Ellyl Ester

Base Information

• Chemical Name: Atorvastatin Ellyl Ester
• CAS No.: 915092-85-2
• Molecular Formula: C36H39FN2O5
• Molecular Weight: 598.714
• Mol file: 915092-85-2.mol

Synonyms:Atorvastatin Allyl Ester;

Chemical Property of Atorvastatin Ellyl Ester

Chemical Property:

• PSA: 104.28000
• LogP: 7.34220
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

AtorvastatinAllylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Atorvastatin Ellyl Ester

There total 2 articles about Atorvastatin Ellyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

lipitor (134523-03-8) + allyl alcohol (107-18-6) → allyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate (915092-85-2)

Guidance literature:

With sulfuric acid; at 0 - 20 ℃; for 2.5h;

DOI:10.1016/j.bmcl.2015.12.069

Reference yield: 50.0%

lipitor (134523-03-8) + allyl bromide (106-95-6) → allyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate (915092-85-2)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 72h;

Reference yield: 72.0%

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) + allyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate (915092-85-2) → allyl 2-((6R,8R)-8-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetate (1353049-83-8)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

upstream raw materials:

lipitor

allyl bromide

allyl alcohol

Downstream raw materials:

allyl 2-((6R,8R)-8-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetate

2-((6R,8R)-8-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetic acid

2-(2,3-dinitrooxypropoxy)ethyl 2-((6R,8R)-8-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetate

(3R,5R)-2-(2,3-bis (nitrooxy)propoxy)ethyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

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