3-O-Acetyl ezetimibe

Base Information

• Chemical Name: 3-O-Acetyl ezetimibe
• CAS No.: 1044664-24-5
• Molecular Formula: C26H23F2NO4
• Molecular Weight: 451.46
• Mol file: 1044664-24-5.mol

Synonyms:2-Azetidinone, 3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-, (3R,4S)-;(1S)-3-[(4S,3R)-1-(4-Fluorophenyl)-4-(4-hydroxyphenyl)-2-oxoazetidin-3-yl]-1-(4-fluorophenyl)propyl acetate;

Chemical Property of 3-O-Acetyl ezetimibe

Chemical Property:

• Boiling Point: 643.414 °C at 760 mmHg
• Flash Point: 342.924 °C
• Density: 1.306 g/cm³
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Dichloromethane, DMSO, Methanol

Purity/Quality:

99% ^*data from raw suppliers

3-O-Acetyl Ezetimibe ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: A derivative of 2-azetidinone with antihyperlipoproteinemic properties.

Technology Process of 3-O-Acetyl ezetimibe

There total 1 articles about 3-O-Acetyl ezetimibe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4(S)-(4-acetyloxyphenyl)-3(R)-(3(S)-acetyloxy-3-(4-fluorophenyl)propyl)-1-(4-fluorophenyl)-2-azetidinone (163380-20-9) → (1S)-1-(4-fluorophenyl)-3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]propyl acetate (190448-46-5,1044664-24-5)

Guidance literature:

With aluminum oxide; In dichloromethane; for 0.05h; microwave irradiation;

DOI:10.1002/anie.200460348

upstream raw materials:

4(S)-(4-acetyloxyphenyl)-3(R)-(3(S)-acetyloxy-3-(4-fluorophenyl)propyl)-1-(4-fluorophenyl)-2-azetidinone