163380-20-9

Basic information

• Product Name: Ezetimibe Diacetate
• Synonyms: Ezetimibe Diacetate;[4-[(2S,3R)-3-[(3R)-3-acetyloxy-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenyl] acetate
• CAS NO: 163380-20-9
• Molecular Formula: C₂₈H₂₅F₂NO₅
• Molecular Weight: 493.4986064
• Product Categories: Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 163380-20-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: Ezetimibe Diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ezetimibe Diacetate(163380-20-9)
• EPA Substance Registry System: Ezetimibe Diacetate(163380-20-9)

Safety Data

• Hazardous Substances Data: 163380-20-9(Hazardous Substances Data)

Usage

Chemical Properties

White Foam

Uses

Protected Ezetimibe derivative.

Upstream product

• 108-24-7 acetic anhydride 
• 163222-33-1 ezetemibe 
• 163222-32-0 (3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4-(4-benzyloxyphenyl)-2-azetidinone 
• 204589-80-0 methyl 3-((2S,3R)-2-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-4-oxoazetidin-3-yl)propanoate 
• 190595-65-4 (3R,4S)-4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one 
• 204589-84-4 3-((3R,4S)-1-(4-fluorophenyl)-2-oxo-4-(4-(benzyloxy)phenyl)azetidin-3-yl)propionic acid chloride 
• 204589-82-2 (3R,4S)-1-(4-fluorophenyl)-3-(3-hydroxy-3-oxopropyl)-4-(4-benzyloxyphenyl)-2-azetidinone 
• 219653-96-0 (Z)-1-(4-(benzyloxy)phenyl)-N-(4-fluorophenyl)methaneimine 
• 75-36-5 acetyl chloride 

Downstream Products

• 190448-46-5 (1S)-1-(4-fluorophenyl)-3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]propyl acetate 

Relevant articles and documents

An in vitro assay for evaluation of small-molecule inhibitors of cholesterol absorption

Giving cholesterol the brush off: An intestinal brush border membrane vesicle assay has been devised for the convenient in vitro testing of small molecules for inhibition of cholesterol absorption. The assay was used to identify new nonhydrolyzable glycosides as potent cholesterol-absorption inhibitors and an oxazolidinone as an effective replacement of the β-lactam scaffold of ezetimibe (1).

Combinations of hydroxy-substituted azetidinone compounds and HMG CoA Reductase Inhibitors

Hydroxy-substituted azetidinone hypocholesterolemic agents of the formula STR1 or a pharmaceutically acceptable salt thereof, wherein: Ar1 and Ar2 are aryl or R4 -substituted aryl; Ar3 is aryl or R5 -

Sugar-Substituted 2-Azetidinone Cholesterol Absorption Inhibitors: Enhanced Potency by Modification of the Sugar

A glucuronide conjugate of the potent 2-azetidinone cholesterol absorbtion inhibitor Sch 58235 was synthesized to confirm the structure of a metabolite isolated from in vivo sources.A series of 2-azetidinone glycosides was prepared via Schmidt trichloroim