21-O-Acetyl 6β-Hydroxy Dexamethasone

Base Information

Chemical Name:21-O-Acetyl 6β-Hydroxy Dexamethasone
CAS No.:72559-77-4
Molecular Formula:C₂₄H₃₁FO₇
Molecular Weight:450.504
Hs Code.:
Mol file:72559-77-4.mol

Synonyms:21-O-Acetyl 6|A-Hydroxy Dexamethasone;(6|A,11|A,16|A)-21-(Acetyloxy)-9-fluoro-6,11,17-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione;

Suppliers and Price of 21-O-Acetyl 6β-Hydroxy Dexamethasone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
21-O-Acetyl6β-HydroxyDexamethasone
25mg
$ 765.00

Total 10 raw suppliers

Chemical Property of 21-O-Acetyl 6β-Hydroxy Dexamethasone

Chemical Property:

PSA：121.13000
LogP:1.43730
Solubility.:Methanol

Purity/Quality:

99% ^*data from raw suppliers

21-O-Acetyl6β-HydroxyDexamethasone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Protected metabolite of Dexamethasone (D298800).

Technology Process of 21-O-Acetyl 6β-Hydroxy Dexamethasone

There total 2 articles about 21-O-Acetyl 6β-Hydroxy Dexamethasone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 59860-91-2
9α-fluoro-3,11β,17α,21-tetrahydroxy-16β-methyl-1,3,5-pregnatriene-20-one 21-acetate 3-benzoate

: 72559-76-3,72559-77-4
9α-fluoro-6β,11β,17α,21-tetrahydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 21-acetate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In chloroform; for 1h; Ambient temperature;

Reference yield: 22.0%

: 987-24-6
betamethasone 21-acetate

: 72559-76-3,72559-77-4
9α-fluoro-6β,11β,17α,21-tetrahydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 21-acetate

Guidance literature:: With selenium(IV) oxide; In 1,4-dioxane; at 80 ℃; for 2.5h;
DOI:10.1080/00397919108020825

Reference yield:

: 72559-76-3,72559-77-4
9α-fluoro-6β,11β,17α,21-tetrahydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 21-acetate

: 82926-63-4
9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 17-butyrate

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / pyridine/ CF₃-COOH/ 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho-p-toluenesulfonate / dimethylsulfoxide; benzene / 16 h / Ambient temperature

2: 75 percent / Na₂CO₃ / methanol / 18 h / Ambient temperature

3: 44 percent / 1.) p-toluenesulfonic acid monohydrate; 2.) 90percent CH₃COOH aq. / Ambient temperature; 1.) DMSO, 4 h; 2.) 4 h

With pyridine; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; sodium carbonate; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; In methanol; dimethyl sulfoxide; benzene;