59860-91-2

Upstream product

• 987-24-6 betamethasone 21-acetate 
• 98-88-4 benzoyl chloride 

Downstream Products

• 72559-76-3 9α-fluoro-6β,11β,17α,21-tetrahydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 21-acetate 
• 72560-07-7 9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 17-benzoate 
• 82926-63-4 9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 17-butyrate 

Relevant academic research and scientific papers

Synthesis and topical antiinflammatory potencies of a series of 6-keto- and Δ6-6-acyloxybetamethasone derivatives

6-Keto and Δ6-6-acyloxybetamethasone esters were synthesized, and tested for topical antiinflammatory potency using a modification of the Tonelli croton ear assay. The introduction of a 6-keto group generally led to retention of topical antiinflammatory potencies when compared to the corresponding 6-desoxycorticoids. In contrast, introduction of the Δ6-6-acyloxy moiety into betamethasone 17,21-dipropionate reduced antiinflammatory potency.

Pharmaceutical compositions of 6α,9α-difluoro-androst-4-ene-17β-carboxylates and derivatives thereof

The specification describes anti-inflammatory steroids having the following formula STR1 wherein X represents a hydrogen or fluorine atom, R' represents a methyl, ethyl, n-propyl or iso-propyl group, R" represents a methyl, chloromethyl, fluoromethyl, bro