4-(2-Bromoethoxy)benzenesulfonyl chloride

Base Information

• Chemical Name: 4-(2-Bromoethoxy)benzenesulfonyl chloride
• CAS No.: 167404-38-8
• Molecular Formula: C8H8BrClO3S
• Molecular Weight: 299.573
• European Community (EC) Number: 844-167-5
• DSSTox Substance ID: DTXSID801269152
• Mol file: 167404-38-8.mol

Synonyms:167404-38-8;4-(2-BROMOETHOXY)BENZENESULFONYL CHLORIDE;4-(2-bromoethoxy)benzene-1-sulfonyl chloride;4-(2-BROMOETHOXY)BENZENE-1-SULFONYLCHLORIDE;SCHEMBL8323215;DTXSID801269152;AKOS000151014;AT12675;4-(2-Bromo-ethoxy)-benzenesulfonyl chloride;CS-0308640;EN300-126251

Chemical Property of 4-(2-Bromoethoxy)benzenesulfonyl chloride

Chemical Property:

• PSA: 51.75000
• LogP: 3.46860
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 297.90661
• Heavy Atom Count: 14
• Complexity: 254

Purity/Quality:

99% ^*data from raw suppliers

4-(2-BROMOETHOXY)BENZENE-1-SULFONYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1OCCBr)S(=O)(=O)Cl

Technology Process of 4-(2-Bromoethoxy)benzenesulfonyl chloride

There total 1 articles about 4-(2-Bromoethoxy)benzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

phenoxyethyl bromide (589-10-6) → 4-(2-bromoethoxy)benzenesulfonyl chloride (167404-38-8)

Guidance literature:

With chlorosulfonic acid; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1021/jm0708533

Reference yield: 78.0%

4-(2-bromoethoxy)benzenesulfonyl chloride (167404-38-8) → 4-(2-bromo-ethoxy)-benzenesulfonamide (125174-28-9)

Guidance literature:

With ammonia; In dichloromethane; at 0 ℃; for 0.75h;

DOI:10.1016/j.ejmech.2012.02.049

Reference yield:

4-(2-bromoethoxy)benzenesulfonyl chloride (167404-38-8) → 4-[(2-(pyrrolidin-1-yl)ethoxy)]benzenesulfonamide (1375453-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia / dichloromethane / 0.75 h / 0 °C

2: ethanol / 20 h / Reflux

With ammonia; In ethanol; dichloromethane;

DOI:10.1016/j.ejmech.2012.02.049

upstream raw materials:

phenoxyethyl bromide

Downstream raw materials:

4-[(2-(pyrrolidin-1-yl)ethoxy)]benzenesulfonamide

4-[(2-(piperidin-1-yl)ethoxy)]benzenesulfonamide

4-{2-[(4-ethoxycarbonyl)piperidin-1-yl]ethoxy}benzenesulfonamide

1-(4-trifluoromethylphenyl)-3-[4-(2-piperidin-1-ylethoxy)benzene]sulfonylurea