1-(4-trifluoromethylphenyl)-3-[4-(2-piperidin-1-ylethoxy)benzene]sulfonylurea

Base Information

• Chemical Name: 1-(4-trifluoromethylphenyl)-3-[4-(2-piperidin-1-ylethoxy)benzene]sulfonylurea
• CAS No.: 1375453-86-3
• Molecular Formula: C₂₁H₂₄F₃N₃O₄S
• Molecular Weight: 471.5
• Mol file: 1375453-86-3.mol

Synonyms:1-(4-trifluoromethylphenyl)-3-[4-(2-piperidin-1-ylethoxy)benzene]sulfonylurea

Chemical Property of 1-(4-trifluoromethylphenyl)-3-[4-(2-piperidin-1-ylethoxy)benzene]sulfonylurea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-trifluoromethylphenyl)-3-[4-(2-piperidin-1-ylethoxy)benzene]sulfonylurea

There total 3 articles about 1-(4-trifluoromethylphenyl)-3-[4-(2-piperidin-1-ylethoxy)benzene]sulfonylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

4-[(2-(piperidin-1-yl)ethoxy)]benzenesulfonamide (1110761-44-8) + p-trifluoromethyl-phenylisocyanate (1548-13-6) → 1-(4-trifluoromethylphenyl)-3-[4-(2-piperidin-1-ylethoxy)benzene]sulfonylurea (1375453-86-3)

Guidance literature:

4-[(2-(piperidin-1-yl)ethoxy)]benzenesulfonamide; With sodium hydroxide; In acetone; for 0.166667h;

p-trifluoromethyl-phenylisocyanate; In acetone; for 4h; Reflux;

DOI:10.1016/j.ejmech.2012.02.049

Reference yield:

4-(2-bromoethoxy)benzenesulfonyl chloride (167404-38-8) → 1-(4-trifluoromethylphenyl)-3-[4-(2-piperidin-1-ylethoxy)benzene]sulfonylurea (1375453-86-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ammonia / dichloromethane / 0.75 h / 0 °C

2.1: ethanol / 20 h / Reflux

3.1: sodium hydroxide / acetone / 0.17 h

3.2: 4 h / Reflux

With ammonia; sodium hydroxide; In ethanol; dichloromethane; acetone;

DOI:10.1016/j.ejmech.2012.02.049

Reference yield:

4-(2-bromo-ethoxy)-benzenesulfonamide (125174-28-9) → 1-(4-trifluoromethylphenyl)-3-[4-(2-piperidin-1-ylethoxy)benzene]sulfonylurea (1375453-86-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol / 20 h / Reflux

2.1: sodium hydroxide / acetone / 0.17 h

2.2: 4 h / Reflux

With sodium hydroxide; In ethanol; acetone;

DOI:10.1016/j.ejmech.2012.02.049

upstream raw materials:

4-[(2-(piperidin-1-yl)ethoxy)]benzenesulfonamide

p-trifluoromethyl-phenylisocyanate

4-(2-bromoethoxy)benzenesulfonyl chloride

4-(2-bromo-ethoxy)-benzenesulfonamide