Ethyl 2-(5-Oxazolyl)benzoate

Base Information

• Chemical Name: Ethyl 2-(5-Oxazolyl)benzoate
• CAS No.: 1186127-15-0
• Molecular Formula: C12H11NO3
• Molecular Weight: 217.22064
• Hs Code.: 2934999090
• Mol file: 1186127-15-0.mol

Synonyms:Ethyl 2-(5-Oxazolyl)benzoate

Chemical Property of Ethyl 2-(5-Oxazolyl)benzoate

Chemical Property:

• PSA: 52.33000
• LogP: 2.51830

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl2-(5-Oxazolyl)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-(5-Oxazolyl)benzoate

There total 2 articles about Ethyl 2-(5-Oxazolyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl 2-formylbenzoate (34046-43-0) + [(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) → ethyl 2-(oxazol-5-yl)benzoate (1186127-15-0)

Guidance literature:

With triethylamine; β‐cyclodextrin; In water; at 50 ℃; for 2h; Green chemistry;

DOI:10.1515/znb-2017-0005

Reference yield: 53.0%

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(triisopropylsilyl)-1,3-oxazole (1186127-11-6) + ethyl 2-iodobenzoate (1829-28-3) → ethyl 2-(oxazol-5-yl)benzoate (1186127-15-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; In 1,4-dioxane; at 80 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2009.06.023

upstream raw materials:

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(triisopropylsilyl)-1,3-oxazole

ethyl 2-iodobenzoate

ethyl 2-formylbenzoate

[(p-methylphenyl)sulfonylmethyl]isonitrile

Refernces

• 1、 Primas, Nicolas,Bouillon, Alexandre,Lancelot, Jean-Charles,Rault, Sylvain. "Synthesis of 2-TIPS-oxazol-5-ylboronic acid pinacol ester: efficient route to 5-(het)aryloxazoles via Suzuki cross-coupling reaction". experimental part. p. 6348 - 6353. Retrieved 2009/12/04.