4-Amino Propofol Hydrochloride

Base Information

• Chemical Name: 4-Amino Propofol Hydrochloride
• CAS No.: 100251-91-0
• Molecular Formula: C12H19NO.ClH
• Molecular Weight: 229.75
• Mol file: 100251-91-0.mol

Synonyms:Phenol, 4-amino-2,6-bis(1-methylethyl)-, hydrochloride (9CI);Phenol, 4-amino-2,6-diisopropyl-, hydrochloride (6CI);4-Amino-2,6-diisopropylphenol hydrochloride;4-Aminopropofol hydrochloride;

Chemical Property of 4-Amino Propofol Hydrochloride

Chemical Property:

• PSA: 46.25000
• LogP: 4.60440
• Solubility.: Methanol

Purity/Quality:

99% ^*data from raw suppliers

4-AminoPropofolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Amino Propofol Hydrochloride

There total 3 articles about 4-Amino Propofol Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2,6-Diisopropyl-4-nitrophenol (1576-14-3) → 4-Amino-2,6-diisopropylphenol hydrochloride (100251-91-0)

Guidance literature:

With hydrogenchloride; tin; In ethanol; for 1h; Heating;

DOI:10.1021/jm970681h

Reference yield: 67.0%

2,6-diisopropyl-4-aminophenol (1988-15-4) → 4-Amino-2,6-diisopropylphenol hydrochloride (100251-91-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; diethyl ether;

Reference yield:

2,6-diisopropylphenol (2078-54-8) → 4-Amino-2,6-diisopropylphenol hydrochloride (100251-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / nitric acid; acetic acid / CH₂Cl₂ / 0 °C

2: 66 percent / Sn; conc. HCl / ethanol / 1 h / Heating

With hydrogenchloride; tin; nitric acid; acetic acid; In ethanol; dichloromethane;

DOI:10.1021/jm020864q

upstream raw materials:

2,6-Diisopropyl-4-nitrophenol

2,6-diisopropylphenol

2,6-diisopropyl-4-aminophenol

Downstream raw materials:

2,6-diisopropyl-4-hydroxyiminocyclohexa-2,5-dien-1-one

N-(4-Hydroxy-3,5-diisopropyl-phenyl)-methanesulfonamide

2,6-di(2-propyl)hydroquinone

2,6-diisopropyl-1,4-benzoquinone