1576-14-3

Basic information

• Product Name: 4-Nitro Propofol
• Synonyms: 4-Nitro Propofol;2,6-Bis(1-Methylethyl)-4-nitro-phenol;2,6-Diisopropyl-4-nitrophenol;4-Nitro-2,6-diisopropylphenol;4-nitro-2,6-di(propan-2-yl)phenol
• CAS NO: 1576-14-3
• Molecular Formula: C₁₂H₁₇NO₃
• Molecular Weight: 223.26828
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1576-14-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-Nitro Propofol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitro Propofol(1576-14-3)
• EPA Substance Registry System: 4-Nitro Propofol(1576-14-3)

Safety Data

• Hazardous Substances Data: 1576-14-3(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

Intermediate in the preparation of Propofol metabolites.

Upstream product

• 108-83-8 diisobutyl ketone 
• 34461-00-2 nitromalondialdehyde sodium salt 
• 2078-54-8 2,6-diisopropylphenol 
• 540-80-7 tert.-butylnitrite 
• 100-02-7 4-nitro-phenol 
• 75-29-6 isopropyl chloride 
• 67-63-0 isopropyl alcohol 
• 181294-58-6 N-tert-butyl-β-formyl-β-nitroenamine 

Downstream Products

• 1988-10-9 2,6-di(2-propyl)hydroquinone 
• 1988-11-0 2,6-diisopropyl-1,4-benzoquinone 
• 2078-54-8 2,6-diisopropylphenol 
• 205443-83-0 trifluoro-acetic acid 2,6-diisopropyl-4-(2,2,2-trifluoro-acetylamino)-phenyl ester 

Relevant articles and documents

Kinase inhibitors (by machine translation)

The present invention relates to certain 4 - (substituted anilino) -2 - (substituted piperi -1 -yl) pyrimidine -5 - carboxamide compounds useful for the treatment or prevention of diseases or medical conditions mediated by signal transduction of CaMMK1 isotype. For example, such compounds and salts thereof may be used to treat or prevent a variety of different cancers. Diseases (including 2 diabetes) and/or immune-mediated diseases. (by machine translation)

A Propofol preparation method

The invention provides a preparation method of propofol, which includes following steps: (1) performing Friedel-crafts reaction to p-nitrophenol and isopropanol or 2-halogenated propane under catalysis of an acid to prepare a compound I; (2) performing acylation protection to the compound I to prepare a compound II; (3) performing a reduction reaction to the compound II to prepare a compound III; (4) performing a diazo-reaction to the compound III to prepare a compound IV; and (5) under a weak reducing agent condition, performing a decomposition reaction to the compound IV and meanwhile carrying out hydrolysis under an alkaline condition to obtain the propofol V. The raw materials of the preparation method are easy to obtain. The preparation method is simple in process and is high in yield.

A convenient method for synthesizing modified 4-nitrophenols

β-Nitroenamine having a formyl group behaves as the synthetic equivalent of unstable nitromalonaldehyde upon treatment with ketones under basic conditions and leads to 2,6-disubstituted 4-nitrophenols. The present method is safer than the conventional one using sodium nitromalonaldehyde and enables the preparation of hitherto unknown nitrophenols.