(2'-Methoxy-[1,1'-biphenyl]-2-yl)diphenylphosphine

Base Information

• Chemical Name: (2'-Methoxy-[1,1'-biphenyl]-2-yl)diphenylphosphine
• CAS No.: 402822-70-2
• Molecular Formula: C25H21OP
• Molecular Weight: 368.415
• DSSTox Substance ID: DTXSID60573745
• Nikkaji Number: J1.329.424K
• Wikidata: Q72469280
• Mol file: 402822-70-2.mol

Synonyms:402822-70-2;(2'-Methoxy-[1,1'-biphenyl]-2-yl)diphenylphosphine;2-(Diphenylphosphino)-2'-methoxybiphenyl;[2-(2-methoxyphenyl)phenyl]-diphenylphosphane;SCHEMBL6395598;DTXSID60573745;BCP21903;AKOS015999745;(2'-Methoxybiphenyl-2-yl)diphenylphosphine;CS-0203268;J-500832;Y-200017;(2'-Methoxy[1,1'-biphenyl]-2-yl)(diphenyl)phosphane

Chemical Property of (2'-Methoxy-[1,1'-biphenyl]-2-yl)diphenylphosphine

Chemical Property:

• Melting Point: 175-176 °C
• Boiling Point: 478.2±28.0 °C(Predicted)
• PSA: 22.82000
• LogP: 5.12040
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 6.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 368.133002287
• Heavy Atom Count: 27
• Complexity: 408

Purity/Quality:

97% ^*data from raw suppliers

(2'-Methoxy-[1,1'-biphenyl]-2-yl)diphenylphosphine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1C2=CC=CC=C2P(C3=CC=CC=C3)C4=CC=CC=C4
• Uses: suzuki reaction

Technology Process of (2'-Methoxy-[1,1'-biphenyl]-2-yl)diphenylphosphine

There total 10 articles about (2'-Methoxy-[1,1'-biphenyl]-2-yl)diphenylphosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-(diphenylphosphinyl)-2'-methoxyl-1,1'-biphenyl (402822-67-7) → 2′-(diphenylphosphino)biphenyl-2-ol (402822-70-2)

Guidance literature:

With trichlorosilane; triethylamine; In toluene; at 120 ℃;

DOI:10.1016/S0040-4039(01)01981-5 DOI:10.1016/j.tet.2004.03.058

Reference yield:

1-Bromo-2-iodobenzene (583-55-1) → 2′-(diphenylphosphino)biphenyl-2-ol (402822-70-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / NaOAc / Pd(OAc)2 / N,N-dimethyl-acetamide / 72 h / 130 °C

2: 100 percent / H₂O₂ / methanol / 1 h / 20 °C

3: 95 percent / PPh₃; K₃PO₄ / Pd(dba)2 / dioxane / 48 h / 105 °C

4: 74 percent / trichlorosilane; triethylamine / toluene / 120 °C

With potassium phosphate; trichlorosilane; dihydrogen peroxide; sodium acetate; triethylamine; triphenylphosphine; palladium diacetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; methanol; N,N-dimethyl acetamide; toluene; 3: Suzuki coupling;

DOI:10.1016/j.tet.2004.03.058

Reference yield:

(2-bromophenyl)diphenylphosphine oxide (88652-74-8) → 2′-(diphenylphosphino)biphenyl-2-ol (402822-70-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / PPh₃; K₃PO₄ / Pd(dba)2 / dioxane / 48 h / 105 °C

2: 74 percent / trichlorosilane; triethylamine / toluene / 120 °C

With potassium phosphate; trichlorosilane; triethylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; toluene; 1: Suzuki coupling;

DOI:10.1016/j.tet.2004.03.058

upstream raw materials:

2-(diphenylphosphinyl)-2'-methoxyl-1,1'-biphenyl

1-Bromo-2-iodobenzene

(2-bromophenyl)diphenylphosphine oxide

Diphenylphosphine oxide

Downstream raw materials:

2-(diphenylphosphinyl)-2'-methoxyl-1,1'-biphenyl

C₂₇H₂₃O₄P