2-(Dicyclohexylphosphino)-2'-methoxybiphenyl

Base Information

• Chemical Name: 2-(Dicyclohexylphosphino)-2'-methoxybiphenyl
• CAS No.: 255835-82-6
• Molecular Formula: C25H33OP
• Molecular Weight: 380.51
• Hs Code.: 2931900090
• DSSTox Substance ID: DTXSID40472949
• Nikkaji Number: J2.103.170D
• Wikidata: Q72468729
• Mol file: 255835-82-6.mol

Synonyms:255835-82-6;2-(Dicyclohexylphosphino)-2'-methoxybiphenyl;Dicyclohexyl(2'-methoxy-[1,1'-biphenyl]-2-yl)phosphine;Dicyclohexyl-[2-(2-methoxyphenyl)phenyl]phosphane;2-(Dicyclohexylphosphino)-2'-methoxy-1,1'-biphenyl;C25H33OP;SCHEMBL1291696;DTXSID40472949;YXJPHYNYXMEWKW-UHFFFAOYSA-N;AMY39346;BCP21901;MFCD19441234;AKOS015999748;AS-69542;CS-0085587;FT-0689980;2-Dicvclohexylphosphino-2'-methoxy-1,1'-biphenyl;2-Dicyclohexylphosphino-2'-methoxy-1,1'-biphenyl;A877547;J-506350;Y-200007;Dicyclohexyl(2'-methoxy[1,1'-biphenyl]-2-yl)phosphane;dicyclohexyl(2'-methoxy[1,1'-biphenyl]-2-yl)phosphine;DICYCLOHEXYL({2'-METHOXY-[1,1'-BIPHENYL]-2-YL})PHOSPHANE;Dicyclohexyl(2'-methoxy-[1 pound not1'-biphenyl]-2-yl)phosphine

Chemical Property of 2-(Dicyclohexylphosphino)-2'-methoxybiphenyl

Chemical Property:

• Melting Point: 120-122℃
• Boiling Point: 504.7±33.0 °C(Predicted)
• PSA: 22.82000
• LogP: 7.13480
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 6.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 380.226902670
• Heavy Atom Count: 27
• Complexity: 408

Purity/Quality:

97% ^*data from raw suppliers

Dicyclohexyl(2'-methoxy-[1,1'-biphenyl]-2-yl)phosphine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1C2=CC=CC=C2P(C3CCCCC3)C4CCCCC4
• Uses: suzuki reaction

Technology Process of 2-(Dicyclohexylphosphino)-2'-methoxybiphenyl

There total 2 articles about 2-(Dicyclohexylphosphino)-2'-methoxybiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-bromo-1-chlorobenzene (694-80-4) + 2-methoxyphenylmagnesium bromide (16750-63-3) + chlorodicyclohexylphosphane (16523-54-9) → dicyclohexyl(2'-methoxy[1,1'-biphenyl]-2-yl)phosphine (255835-82-6)

Guidance literature:

2-bromo-1-chlorobenzene; 2-methoxyphenylmagnesium bromide; With magnesium; In tetrahydrofuran; at 60 ℃; for 2.5h;

chlorodicyclohexylphosphane; With copper(l) chloride; In tetrahydrofuran; at 20 ℃; for 16h; Further stages.;

DOI:10.1021/jo010025w

Reference yield:

1,1'-bis(dicyclohexylphosphino)binaphthyl + chlorodicyclohexylphosphane (16523-54-9) → dicyclohexyl(2'-methoxy[1,1'-biphenyl]-2-yl)phosphine (255835-82-6)

Guidance literature:

In tetrahydrofuran; hexane;

Reference yield: 98.0%

dicyclohexyl(2'-methoxy[1,1'-biphenyl]-2-yl)phosphine (255835-82-6) → 2'-dicyclohexylphosphanyl-6-methoxy-biphenyl-3-sulfonic acid

Guidance literature:

With sulfuric acid; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmc.2018.07.028

upstream raw materials:

2-bromo-1-chlorobenzene

2-methoxyphenylmagnesium bromide

chlorodicyclohexylphosphane

Downstream raw materials:

2-hydroxy-2′-dicyclohexylphosphinobiphenyl

N-(p-tolyl)indole