2'-(Dicyclohexylphosphino)biphenyl-2-ol

Base Information

• Chemical Name: 2'-(Dicyclohexylphosphino)biphenyl-2-ol
• CAS No.: 304435-67-4
• Molecular Formula: C24H31 O P
• Molecular Weight: 366.483
• Hs Code.: 2907199090
• DSSTox Substance ID: DTXSID10426737
• Nikkaji Number: J1.543.043E
• Wikidata: Q82239561
• Mol file: 304435-67-4.mol

Synonyms:304435-67-4;2'-(Dicyclohexylphosphino)biphenyl-2-ol;2-(2-dicyclohexylphosphanylphenyl)phenol;2'-(DICYCLOHEXYLPHOSPHANYL)-[1,1'-BIPHENYL]-2-OL;ZINC02510824;starbld0001567;SCHEMBL2318542;DTXSID10426737;2-(DICYCLOHEXYLPHOSPHINO)-2'-HYDROXYBIPHENYL

Chemical Property of 2'-(Dicyclohexylphosphino)biphenyl-2-ol

Chemical Property:

• Melting Point: 124-126°C
• Boiling Point: 522.4±33.0 °C(Predicted)
• PKA: 9.75±0.30(Predicted)
• PSA: 33.82000
• LogP: 6.83180
• XLogP3: 6.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 366.211252606
• Heavy Atom Count: 26
• Complexity: 394

Purity/Quality:

98%Min ^*data from raw suppliers

2-(DICYCLOHEXYLPHOSPHINO)-2'-HYDROXYBIPHENYL 95.00% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)P(C2CCCCC2)C3=CC=CC=C3C4=CC=CC=C4O

Technology Process of 2'-(Dicyclohexylphosphino)biphenyl-2-ol

There total 6 articles about 2'-(Dicyclohexylphosphino)biphenyl-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dicyclohexyl(2'-methoxy[1,1'-biphenyl]-2-yl)phosphine (255835-82-6) → 2-hydroxy-2′-dicyclohexylphosphinobiphenyl (304435-67-4)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/jo010025w

Reference yield:

dibenzofuran (132-64-9,214827-48-2) + chlorodicyclohexylphosphane (16523-54-9) → 2-hydroxy-2′-dicyclohexylphosphinobiphenyl (304435-67-4)

Guidance literature:

dibenzofuran; With 4,4'-di-tert-butylbiphenyl; lithium; In diethyl ether; for 24h; Heating; sonication;

chlorodicyclohexylphosphane; In diethyl ether; at 20 ℃; for 15h;

With chloro-trimethyl-silane; In diethyl ether; at 20 ℃; for 15h; Further stages.;

DOI:10.1002/chem.200305562

Reference yield:

2-bromo-1-chlorobenzene (694-80-4) + 2-methoxyphenylmagnesium bromide (16750-63-3) + chlorodicyclohexylphosphane (16523-54-9) → 2-hydroxy-2′-dicyclohexylphosphinobiphenyl (304435-67-4)

Guidance literature:

2-bromo-1-chlorobenzene; 2-methoxyphenylmagnesium bromide; With magnesium; In tetrahydrofuran; at 60 ℃;

chlorodicyclohexylphosphane; With copper(l) chloride; In tetrahydrofuran;

With boron tribromide; sodium hydrogencarbonate; In dichloromethane;

DOI:10.1039/c4cy01498g

upstream raw materials:

dicyclohexyl(2'-methoxy[1,1'-biphenyl]-2-yl)phosphine

dibenzofuran

chlorodicyclohexylphosphane

2-bromo-1-chlorobenzene

Downstream raw materials:

2'-dicyclohexylphosphanyl-6-hydroxy-biphenyl-3-sulfonic acid