(S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl]ethyl]propanamide

Base Information

Chemical Name:(S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl]ethyl]propanamide
CAS No.:196597-86-1
Molecular Formula:C17H22BrNO2
Molecular Weight:352.271
Hs Code.:
Mol file:196597-86-1.mol

Synonyms:(S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl]ethyl]propanamide;(S)-N-[2-[5-BroMo-2,3-dihydro-6-hydroxy-7-(2-propenyl)-1H-inden-1-yl]ethyl]propanaM;N-[2-[(1S)-5-BroMo-2,3-dihydro-6-hydroxy-7-(2-propen-1-yl)-1H-inden-1-yl]ethyl]propanaMide

Suppliers and Price of (S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl]ethyl]propanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl]ethyl]propanamide
10 mg
$ 290.00

Biosynth Carbosynth
(S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl]ethyl]propanamide
50 mg
$ 1529.00

Biosynth Carbosynth
(S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl]ethyl]propanamide
25 mg
$ 841.00

Biosynth Carbosynth
(S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl]ethyl]propanamide
10 mg
$ 462.50

Biosynth Carbosynth
(S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl]ethyl]propanamide
5 mg
$ 254.40

Biosynth Carbosynth
(S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl]ethyl]propanamide
2 mg
$ 139.90

Total 6 raw suppliers

Chemical Property of (S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl]ethyl]propanamide

Chemical Property:

Melting Point:85-87 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Boiling Point:483.1±45.0 °C(Predicted)
PKA:9.15±0.40(Predicted)
PSA：52.82000
Density:1.301±0.06 g/cm3(Predicted)
LogP:4.66960
Solubility.:Chloroform, Dichloromethane, Methanol

Purity/Quality:

99% ^*data from raw suppliers

(S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl]ethyl]propanamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Intermediate in the production of Ramelteon.

Technology Process of (S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl]ethyl]propanamide

There total 7 articles about (S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl]ethyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 196597-85-0
(S)-N-[2-(6-allyloxy-5-bromo-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide

: 196597-86-1
(S)-N-[2-(7-allyl-5-bromo-6-hydroxy-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide

Guidance literature:: In various solvent(s); at 200 - 205 ℃;
DOI:10.1021/jm0201159

Reference yield:

: 13623-25-1
6-methoxy-2,3-dihydro-1H-inden-1-one

: 196597-86-1
(S)-N-[2-(7-allyl-5-bromo-6-hydroxy-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH / tetrahydrofuran / 20 °C

1.2: tetrahydrofuran / 20 °C

2.1: H₂; ethanolic NH₃ / Raney-Co

3.1: Et₃N / tetrahydrofuran / 0 °C

4.1: 86 percent / NaOAc; Br₂ / 0 °C

5.1: 94 percent / BBr₃ / CH₂Cl₂ / 0.67 h / -20 - 20 °C

6.1: NaH / dimethylformamide / 0 °C

6.2: 96 percent / dimethylformamide / 0 °C

7.1: 80 percent / various solvent(s) / 200 - 205 °C

With ammonia; hydrogen; bromine; sodium acetate; boron tribromide; sodium hydride; triethylamine; Raney-Co; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.2: Horner-Emmons reaction / 7.1: Claisen rearrangement;
DOI:10.1021/jm0201159

Reference yield:

: 187871-98-3
(E)-(2,3-dihydro-6-methoxy-1H-inden-1-ylidene)acetonitrile

: 196597-86-1
(S)-N-[2-(7-allyl-5-bromo-6-hydroxy-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: H₂; ethanolic NH₃ / Raney-Co

2.1: Et₃N / tetrahydrofuran / 0 °C

3.1: 86 percent / NaOAc; Br₂ / 0 °C

4.1: 94 percent / BBr₃ / CH₂Cl₂ / 0.67 h / -20 - 20 °C

5.1: NaH / dimethylformamide / 0 °C

5.2: 96 percent / dimethylformamide / 0 °C

6.1: 80 percent / various solvent(s) / 200 - 205 °C

With ammonia; hydrogen; bromine; sodium acetate; boron tribromide; sodium hydride; triethylamine; Raney-Co; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 6.1: Claisen rearrangement;
DOI:10.1021/jm0201159