12-AMINO-1-DODECANOIC ACID, METHYL ESTER, HYDROCHLORIDE SALT

Base Information

• Chemical Name: 12-AMINO-1-DODECANOIC ACID, METHYL ESTER, HYDROCHLORIDE SALT
• CAS No.: 22543-30-2
• Molecular Formula: C₁₂H₂₅NO₂*ClH
• Molecular Weight: 251.797
• Mol file: 22543-30-2.mol

Synonyms:12-AMINO-1-DODECANOIC ACID, METHYL ESTER, HYDROCHLORIDE SALT;METHYL 12-AMINODODECANOATE, HCL;METHYL 12-AMINODODECANOATE, HYDROCHLORIDE;12-aMinododecanoic acid hydrochloride

Chemical Property of 12-AMINO-1-DODECANOIC ACID, METHYL ESTER, HYDROCHLORIDE SALT

Chemical Property:

• Vapor Pressure: 7.57E-07mmHg at 25°C
• Melting Point: 157-160°C
• Boiling Point: 380.6°C at 760 mmHg
• Flash Point: 184°C
• PSA: 63.32000
• LogP: 4.43300
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

95% ^*data from raw suppliers

12-Amino-1-dodecanoicAcidMethylEsterHClSalt 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 12-AMINO-1-DODECANOIC ACID, METHYL ESTER, HYDROCHLORIDE SALT

There total 7 articles about 12-AMINO-1-DODECANOIC ACID, METHYL ESTER, HYDROCHLORIDE SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-azacyclotridecanone (947-04-6,25038-74-8) → 12-aminolauric acid hydrogen chloride salt (22543-30-2)

Guidance literature:

With hydrogenchloride; water; at 150 ℃; for 24h;

DOI:10.1021/ic201654d

Reference yield:

12-Aminododecanoic acid (693-57-2) → 12-aminolauric acid hydrogen chloride salt (22543-30-2)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2010.03.077

Reference yield:

10-undecenoic acid (112-38-9) → 12-aminolauric acid hydrogen chloride salt (22543-30-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: methanol / 6 h / 0 - 20 °C

2.1: ozone; triphenylphosphine / methanol; dichloromethane / 6 h / -78 - 20 °C

3.1: cyanoacetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

3.2: 45004.5 Torr / Inert atmosphere

4.1: hydrogenchloride / water / 2.5 h / Reflux

With hydrogenchloride; ozone; cyanoacetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; 3.1: Knoevenagel condensation;

DOI:10.5012/bkcs.2012.33.6.1873

upstream raw materials:

12-Aminododecanoic acid

2-azacyclotridecanone

methyl 12-aminododecanoate acetic acid salt

10-undecenoic acid

Downstream raw materials:

Benzyloxycarbonyl-bis-(12-amino-dodecansaeure)-hydrazid

Benzyloxycarbonyl-bis-(12-amino-dodecansaeure)-methylester

12-(((benzyloxy)carbonyl)amino)dodecanoic acid

Refernces

• 1、 Koh, Moo-Hyun,Kim, Hyeonjeong,Shin, Nara,Kim, Hyun Su,Yoo, Dongwon,Kim, Young Gyu. "Divergent process for C10, C11 and C12 ω-amino acid and α,ω-dicarboxylic acid monomers of polyamides from castor oil as a renewable resource". experimental part. p. 1873 - 1878. Retrieved 2012/08/07.