N-(12-Aminododecyl)-1-deoxynojirimycin

Base Information

• Chemical Name: N-(12-Aminododecyl)-1-deoxynojirimycin
• CAS No.: 885484-41-3
• Molecular Formula: C₁₂H₂₆N₂O₄
• Molecular Weight: 262.349
• Hs Code.: 29329990
• Mol file: 885484-41-3.mol

Synonyms:N-(12-Aminododecyl)-1-deoxynojirimycin

Chemical Property of N-(12-Aminododecyl)-1-deoxynojirimycin

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 522.474°C at 760 mmHg
• Flash Point: 269.783°C
• PSA: 110.18000
• Density: 1.106g/cm³
• LogP: 1.24350
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

N-(12-Aminododecyl)deoxynojirimycin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-(12-Aminododecyl)-1-deoxynojirimycin is used in the preparation of imino-alditols as glycosidase inhibitors.

Technology Process of N-(12-Aminododecyl)-1-deoxynojirimycin

There total 3 articles about N-(12-Aminododecyl)-1-deoxynojirimycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-((2R,3R,4R,5S)-3,4,5-Trihydroxy-2-hydroxymethyl-piperidin-1-yl)-hexanenitrile (885484-34-4) → (2R,3R,4R,5S)-1-(6-Amino-hexyl)-2-hydroxymethyl-piperidine-3,4,5-triol (885484-41-3)

Guidance literature:

With hydrogen; nickel; In methanol; for 24h; under 37503 Torr;

DOI:10.1016/j.bmcl.2006.01.095

Reference yield:

1,5-dideoxy-1,5-imino-D-glucitol (19130-96-2) → (2R,3R,4R,5S)-1-(6-Amino-hexyl)-2-hydroxymethyl-piperidine-3,4,5-triol (885484-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂CO₃ / dimethylformamide / 72 h / 40 °C

2: H₂ / Raney-Ni / methanol / 24 h / 37503 Torr

With hydrogen; sodium carbonate; nickel; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.01.095

Reference yield:

6-bromo-1-hexanenitrile (6621-59-6) → (2R,3R,4R,5S)-1-(6-Amino-hexyl)-2-hydroxymethyl-piperidine-3,4,5-triol (885484-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂CO₃ / dimethylformamide / 72 h / 40 °C

2: H₂ / Raney-Ni / methanol / 24 h / 37503 Torr

With hydrogen; sodium carbonate; nickel; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.01.095

upstream raw materials:

6-((2R,3R,4R,5S)-3,4,5-Trihydroxy-2-hydroxymethyl-piperidin-1-yl)-hexanenitrile

1,5-dideoxy-1,5-imino-D-glucitol

6-bromo-1-hexanenitrile