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19130-96-2

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Product FOB Price Min.Order Supply Ability Supplier
1-Deoxynojirimycin
Cas No: 19130-96-2
No Data 20 Metric Ton ask for detail Metric Ton/Day Chengdu Herbpurify Co., Ltd Contact Supplier
1-Deoxynojirimycin manufacturer
Cas No: 19130-96-2
No Data No Data No Data Shanghai Yuanye Bio-Technology Co., Ltd. Contact Supplier
1-Deoxynojirimycin Manufacturer/High quality/Best price/In stock
Cas No: 19130-96-2
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
Mulberry Leaf Extract
Cas No: 19130-96-2
USD $ 27.0-27.0 / Kilogram 1 Kilogram 300 Kilogram/Month Greenutra Resource Inc Contact Supplier
Mulberry Leaf extract powder active ingredients of DNJ /mulberry leaf powder
Cas No: 19130-96-2
USD $ 3.0-3.0 / Gram 1 Gram 10 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
High purity 19130-96-2 1-Deoxynojirimycin
Cas No: 19130-96-2
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
1-Deoxynojirimycin
Cas No: 19130-96-2
USD $ 180.0-200.0 / Kilogram 1 Kilogram 1000 Kilogram/Month Kono Chem Co.,Ltd Contact Supplier
High quality 1-Deoxynojirimycin 1% supplier in China
Cas No: 19130-96-2
No Data No Data No Data Simagchem Corporation Contact Supplier
1-Deoxynojirimycin
Cas No: 19130-96-2
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Deoxynorjirimycin
Cas No: 19130-96-2
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier

19130-96-2 Usage

Definition

ChEBI: An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.

Alkaloids

1-deoxynojirimycin  is referred DNJ for short  , it is an alkaloid extracted from the bark of mulberry leaves and roots, but it also exists in other plants and microorganisms. This product is an effective α-glucosidase inhibitor, it has significant hypoglycemic effect. After 1-deoxynojirimycin goes into the human body, it can inhibit sucrose, maltase, α-glucosidase enzyme, α-amylase decomposing  starch, sugar in the human body , thereby it can block the body's absorption of sugar, inhibiting blood sugar rising to achieve the effect of prevention and treatment of diabetes, the use of it does not cause changes in diet . In addition, DNJ can inhibit glucose modification process of HIV tunica glycoprotein , at the same time, the accumulation of immature glycoproteins may inhibit cell fusion, viral and host cell receptor can combine,which causes  syncytia formation to inhibit the replication of  MoLV ,then the virus activity is inhibited.
Nojirimycin is first discovered from Streptomyces, and natural DNJ is first isolated from the bark of mulberry root. In plants, from mulberry, dayflower, hyacinth and Adenophora plants, DNJ has been isolated and identified ,  DNJ has the highest content in the mulberry and because of mulberry varieties, medicinal parts, seasonal climate, geography, soil, leaf position, different developmental stages  and other factors , there is a big difference. In a microorganism, from a variety of Streptomyces and Bacillus,DNJ is isolated ,it is also found that two kinds of endophytes separated from Mulberry including Stenotrophomonas oligotrophic Pseudomonas and Micrococcus can produce DNJ,fermentation conditions of a variety of  microbial production of DNJ are studied. In insects, in addition to silkworm rich in DNJ , single or oligophagous insects with eating mulberry leaves habit including wild silkworm, mulberry geometrid, Diaphania pyloalis Walker , mulberry white capterpillar are also rich in DNJ , DNJ in insects bodies are from the food , content of DNJ in Bombyx bodies is different due to the different varieties of silkworm, developmental stages, tissues and organs as well as feed and other factors, with the silkworm age of progress ,there is the existence of cyclical changes in absorption and accumulation and excretion of DNJ. Now DNJ biosynthetic pathways in Streptomyces, Bacillus and Commelina bodies are explored and it is found that  synthesis of DNJ has different mechanisms in different species . In addition, three main synthesis methods of 1-deoxynojirimycin are proven , some of the synthetic derivatives of DNJ have been used clinically.
Recent studies show that the active ingredient of mulberry DNJ (l-deoxynojirimycin), only exists in mulberry leaves , by blocking the α-glucosidase enzymes to hinder sugar  becoming to glucose, mulberry leaf extract can inhibit intestinal glucose absorption. This can suppress the blood sugar level and blood pressure rising , and it can have good inhibitory effect on variability of imidazopyridine, benzopyrene and other carcinogenic substances,it has anti-cancer effect, at the same time ,mulberry leaf extract can reduce cholesterol, and improve liver function and eliminate constipation and so on.

Uses

Deoxynojirimycin inhibits mammalian glucosidase 1. As well, it inhibits intestinal and lysosmal alpha-glucosidases, beta-glucosidase from sweet almonds, pancreatic alpha-amylase and amyloglucosidase.

Biological Activity

Inhibitor of glucosidase I (K i = 2.1 mM) and II (K i = 7 mM).

Chemical Properties

White Crystalline Solid

Chemical Name

(2R,3R,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol

Uses

An inhibitor of α-glucosidase I and II
InChI:InChI=1/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3?,4?,5-,6-/m1/s1

19130-96-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name duvoglustat

1.2 Other means of identification

Product number -
Other names (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:19130-96-2 SDS

19130-96-2Related news

Preparation of 1-Deoxynojirimycin (cas 19130-96-2) controlled release matrix pellets of capsules and evaluation in vitro-in vivo to enhance bioavailability07/23/2019

1-deoxynojirimycin was used for the treatment of type II diabetes. However, due to its poor water solubility and low oral bioavailability, clinical application was limited. This study aimed to prepare controlled release matrix pellets of 1-deoxynojirimycin to enhance its oral bioavailability. Th...detailed

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