6-Azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 6-Azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester
• CAS No.: 955028-67-8
• Molecular Formula: C12H21NO2
• Molecular Weight: 211.16
• Mol file: 955028-67-8.mol

Synonyms:tert-Butyl 6-azaspiro[2.5]octane-6-carboxylate;6-Azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester;6-Azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester;6-Azaspiro[2.5]Octane-6-Carboxylic Acid, 1,1-Dimethylethyl Ester(WX100459)

Chemical Property of 6-Azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester

Chemical Property:

• PSA: 29.54000
• LogP: 2.73540

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl6-azaspiro[2.5]octane-6-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester

There total 4 articles about 6-Azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.2%

diiodomethane (75-11-6) + tert-butyl 4-methylidenepiperidine-1-carboxylate (159635-49-1) → tert-butyl 6-azaspiro[2.5]octane-6-carboxylate (955028-67-8)

Guidance literature:

diiodomethane; With diethylzinc; In dichloromethane; at -40 ℃; for 0.5h; Inert atmosphere;

tert-butyl 4-methylidenepiperidine-1-carboxylate; In dichloromethane; at -5 ℃; Inert atmosphere;

Reference yield: 40.0%

bromomethyl bis(catechol)silicate-18-crown-6-potassium + tert-butyl 4-methylidenepiperidine-1-carboxylate (159635-49-1) → tert-butyl 6-azaspiro[2.5]octane-6-carboxylate (955028-67-8)

Guidance literature:

With [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; In dimethyl sulfoxide; at 20 ℃; for 72h; Inert atmosphere; Irradiation;

DOI:10.1002/ejoc.202000134

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 6-azaspiro[2.5]octane hydrobromide (1260527-32-9) → tert-butyl 6-azaspiro[2.5]octane-6-carboxylate (955028-67-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

di-tert-butyl dicarbonate

6-azaspiro[2.5]octane hydrobromide

N-cbz-6-azaspiro[2.5]octane

diiodomethane

Downstream raw materials:

(+/-)-(2-methyl-5-phenylthiazol-4-yl)(5-((6-methylpyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)methanone

(+/-)-(2-methyl-5-phenylthiazol-4-yl)(5-((5-(trifluoromethyl)pyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)methanone

(+/-)methyl 2-(6-azaspiro[2.5]octan-5-ylmethylamino)-5-chlorobenzoate

(+/-)-(5-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-methyl-5-phenylthiazol-4-yl)methanone