(+/-)methyl 2-(6-azaspiro[2.5]octan-5-ylmethylamino)-5-chlorobenzoate

Base Information

• Chemical Name: (+/-)methyl 2-(6-azaspiro[2.5]octan-5-ylmethylamino)-5-chlorobenzoate
• CAS No.: 1260527-40-9
• Molecular Formula: C₁₆H₂₁ClN₂O₂
• Molecular Weight: 308.808
• Mol file: 1260527-40-9.mol

Synonyms:(+/-)methyl 2-(6-azaspiro[2.5]octan-5-ylmethylamino)-5-chlorobenzoate

Chemical Property of (+/-)methyl 2-(6-azaspiro[2.5]octan-5-ylmethylamino)-5-chlorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)methyl 2-(6-azaspiro[2.5]octan-5-ylmethylamino)-5-chlorobenzoate

There total 6 articles about (+/-)methyl 2-(6-azaspiro[2.5]octan-5-ylmethylamino)-5-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorobenzenesulfonyl chloride (5202-89-1) + (+/-) tert-butyl 5-formyl-6-azaspiro[2.5]octane-6-carboxylate (1260527-33-0) → (+/-)methyl 2-(6-azaspiro[2.5]octan-5-ylmethylamino)-5-chlorobenzoate (1260527-40-9)

Guidance literature:

4-chlorobenzenesulfonyl chloride; (+/-) tert-butyl 5-formyl-6-azaspiro[2.5]octane-6-carboxylate; With acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 3h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

Reference yield:

C16H19ClN2O2 → (+/-)methyl 2-(6-azaspiro[2.5]octan-5-ylmethylamino)-5-chlorobenzoate (1260527-40-9)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,1-dichloroethane; acetic acid;

Reference yield:

tert-butyl 6-azaspiro[2.5]octane-6-carboxylate (955028-67-8) → (+/-)methyl 2-(6-azaspiro[2.5]octan-5-ylmethylamino)-5-chlorobenzoate (1260527-40-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / hexane; diethyl ether / -60 - 20 °C

1.2: 0.5 h / -78 °C

2.1: acetic acid / 1,1-dichloroethane / 3 h / 20 °C

3.1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane; acetic acid

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium tris(acetoxy)borohydride; acetic acid; In diethyl ether; 1,1-dichloroethane; hexane; acetic acid;

upstream raw materials:

4-chlorobenzenesulfonyl chloride

(+/-) tert-butyl 5-formyl-6-azaspiro[2.5]octane-6-carboxylate

tert-butyl 6-azaspiro[2.5]octane-6-carboxylate

N-cbz-6-azaspiro[2.5]octane

Downstream raw materials:

(+/-)-methyl 5-chloro-2-((6-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)-6-azaspiro[2.5]octan-5-yl)methylamino)benzoate