ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

Base Information

• Chemical Name: ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate
• CAS No.: 1186189-28-5
• Molecular Formula: C11H10N2O4
• Molecular Weight: 234.211
• Hs Code.: 2933990090
• Mol file: 1186189-28-5.mol

Synonyms:ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate;ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylat

Chemical Property of ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

Chemical Property:

• Boiling Point: 388.1±52.0 °C(Predicted)
• PKA: 4.50±1.00(Predicted)
• PSA: 92.28000
• Density: 1.46±0.1 g/cm3(Predicted)
• LogP: 0.80540

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2,4-Dihydroxy-1,8-naphthyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

There total 6 articles about ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

methyl 2-aminonicotinate (14667-47-1) + diethyl malonate (105-53-3) → ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate (1186189-28-5)

Guidance literature:

With sodium ethanolate; In ethanol; for 6h; Reflux;

DOI:10.1016/j.ejmech.2012.03.031

Reference yield: 50.0%

2-Methyl-4H-pyrido<2,3-d><3,1>oxazin-4-one (3809-93-6) + diethyl malonate (105-53-3) → ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate (1186189-28-5)

Guidance literature:

diethyl malonate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere; Sealed tube;

2-Methyl-4H-pyrido<2,3-d><3,1>oxazin-4-one; In tetrahydrofuran; mineral oil; at 70 ℃; for 0.166667h; Inert atmosphere; Sealed tube; Microwave irradiation;

DOI:10.1002/jhet.1869

Reference yield:

methyl 2-[(3-ethoxy-3-oxo-propanoyl)amino]pyridine-3-carboxylate → ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate (1186189-28-5)

Guidance literature:

With sodium ethanolate; In ethanol; at 90 ℃; for 1h;

upstream raw materials:

methyl 2-aminonicotinate

diethyl malonate

2-Methyl-4H-pyrido<2,3-d><3,1>oxazin-4-one

2-aminopyridin-3-carboxylic acid

Downstream raw materials:

N-cyclohexyl-1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

N-cyclohexyl-1-(p-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

N-cyclohexyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1186189-28-5 ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send