2-Chloro-5-phenylthiazole

Base Information

• Chemical Name: 2-Chloro-5-phenylthiazole
• CAS No.: 329794-40-3
• Molecular Formula: C9H6ClNS
• Molecular Weight: 195.672
• Mol file: 329794-40-3.mol

Synonyms:2-Chlor-4-phenylthiazol;2-CHLORO-5-PHENYLTHIAZOLE;2-chloranyl-5-phenyl-1,3-thiazole;

Chemical Property of 2-Chloro-5-phenylthiazole

Chemical Property:

• Melting Point: 40-42 °C
• Boiling Point: 338.3±35.0 °C(Predicted)
• PKA: 0.52±0.10(Predicted)
• PSA: 41.13000
• Density: 1.309±0.06 g/cm3(Predicted)
• LogP: 3.46350

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-5-phenylthiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-5-phenylthiazole

There total 5 articles about 2-Chloro-5-phenylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-chloro-5-(4,4,5,5-tetramethyl-1,3-dioxaborolan-2-yl)thiazole (889672-72-4) + iodobenzene (591-50-4) → 2-chloro-5-phenyl-thiazole (329794-40-3)

Guidance literature:

With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 170 ℃; microwave irradiation;

DOI:10.1021/jo0601009

Reference yield: 54.0%

5-phenyl-1,3-thiazol-2-amine (39136-63-5) → 2-chloro-5-phenyl-thiazole (329794-40-3)

Guidance literature:

With copper dichloride; isopentyl nitrite; In acetonitrile; at 20 ℃;

Reference yield: 13.0%

2-chloro-5-(4,4,5,5-tetramethyl-1,3-dioxaborolan-2-yl)thiazole (889672-72-4) + para-iodoanisole (696-62-8) → 2-chloro-5-(4-methoxyphenyl)thiazole + 2-chloro-5-phenyl-thiazole (329794-40-3)

Guidance literature:

With caesium carbonate; In 1,4-dioxane; at 170 ℃; for 0.333333h; microwave irradiation;

DOI:10.1021/jo0601009

upstream raw materials:

5-phenyl-1,3-thiazol-2-amine

2-chlorothiazole

iodobenzene

2-chloro-5-(4,4,5,5-tetramethyl-1,3-dioxaborolan-2-yl)thiazole

Downstream raw materials:

(5-phenyl-thiazol-2-yl)-hydrazine

Refernces

• 1、 -. "HETEROCYCLIC KINASE MODULATORS". Page/Page column 112. . Retrieved 2009/01/20.
• 2、 Hafez, Ebtissam Abdel Aziz,Abed, Nosrat Mustafa,Elsakka, Ibrahim Ahmed. "Reactions With Heterocyclic Diazonium Salts. Synthesis of Several New Azolylhydrazones". . p. 285 - 288. Retrieved 2007/10/02.