5-Phenylthiazol-2-amine

Base Information

• Chemical Name: 5-Phenylthiazol-2-amine
• CAS No.: 39136-63-5
• Molecular Formula: C9H8N2S
• Molecular Weight: 176.242
• Hs Code.: 2934100090
• European Community (EC) Number: 254-312-9
• DSSTox Substance ID: DTXSID50192383
• Nikkaji Number: J261.318B
• Wikidata: Q72498874
• Mol file: 39136-63-5.mol

Synonyms:5-phenyl-thiazol-2-ylamine

Chemical Property of 5-Phenylthiazol-2-amine

Chemical Property:

• Vapor Pressure: 1.8E-05mmHg at 25°C
• Melting Point: 256-257℃
• Refractive Index: 1.659
• Boiling Point: 363.4 °C at 760 mmHg
• Flash Point: 173.6 °C
• PSA: 67.15000
• Density: 1.261 g/cm³
• LogP: 2.97350
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 176.04081944
• Heavy Atom Count: 12
• Complexity: 146

Purity/Quality:

99.0% ^*data from raw suppliers

5-Phenyl-1,3-thiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CN=C(S2)N

Technology Process of 5-Phenylthiazol-2-amine

There total 13 articles about 5-Phenylthiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-phenylthiazol-2-azide → 5-phenyl-1,3-thiazol-2-amine (39136-63-5)

Guidance literature:

With D-glucose; potassium hydroxide; In water; at 85 ℃; for 0.166667h; chemoselective reaction; Green chemistry;

DOI:10.1039/c7gc01593c

Reference yield: 89.0%

2-bromo-1,1-dimethoxy-2-phenylethane (14371-25-6) + thiourea (17356-08-0) → 5-phenyl-1,3-thiazol-2-amine (39136-63-5)

Guidance literature:

With hydrogen bromide; at 100 ℃; for 2h;

DOI:10.1021/ja00085a008

Reference yield: 80.0%

α-bromophenylacetaldehyde (16927-13-2) + thiourea (17356-08-0) → 5-phenyl-1,3-thiazol-2-amine (39136-63-5)

Guidance literature:

In ethanol; for 8h; Reflux;

upstream raw materials:

phenylacetaldehyde

thiourea

2-chloro-2-phenylacetaldehyde

(1-chloro-2-nitroso-ethyl)-benzene

Downstream raw materials:

3-[(5-phenyl-thiazol-2-ylamino)-methyl]-5-(2,4,5-trichloro-phenoxymethyl)-3H-[1,3,4]oxadiazole-2-thione

(5-phenyl-thiazol-2-yl)-carbamic acid ethyl ester

N-(5-phenyl-thiazol-2-yl)-acetamide

2,8-diphenyl-benzo[1'',2'':4,5;5'',4'':4',5']diimidazo[2,1-b;2',1'-b']bisthiazole-5,11-dione