2-(benzyloxy)-5-methylpyridine

Base Information

• Chemical Name: 2-(benzyloxy)-5-methylpyridine
• CAS No.: 92028-39-2
• Molecular Formula: C13H13NO
• Molecular Weight: 199.252
• Hs Code.: 2933399090
• Mol file: 92028-39-2.mol

Synonyms:Pyridine,5-methyl-2-(phenylmethoxy);2-benzyloxy-5-methylpyridine;2-(3-CHLOROPHENYL)-ISONICOTINIC ACID;PYR213;2-Benzyloxy-5-methyl-pyridin;

Chemical Property of 2-(benzyloxy)-5-methylpyridine

Chemical Property:

• PSA: 22.12000
• LogP: 2.96900
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(Benzyloxy)-5-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(benzyloxy)-5-methylpyridine

There total 3 articles about 2-(benzyloxy)-5-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-chloro-5-methylpyridine (18368-64-4) + benzyl alcohol (100-51-6,185532-71-2) → 2-(benzyloxy)-5-methylpyridine (92028-39-2)

Guidance literature:

With potassium tert-butylate; In 1,4-dioxane; at 98 ℃; for 18h;

DOI:10.1021/jo800866w

Reference yield: 78.0%

2-chloro-5-methylpyridine (18368-64-4) + 4-Methylbenzyl alcohol (589-18-4) → 2-(benzyloxy)-5-methylpyridine (92028-39-2)

Guidance literature:

With potassium tert-butylate; In 1,4-dioxane; at 98 ℃; for 19h;

DOI:10.1021/jo3015424

Reference yield:

→ 2-(benzyloxy)-5-methylpyridine (92028-39-2)

Guidance literature:

Benzylalkohol, 1) KOH, Xylol, Δ, 2) 5-Brom-2-methyl-pyridin, 200grad;

DOI:10.1039/jr9620001475

upstream raw materials:

2-chloro-5-methylpyridine

benzyl alcohol

4-Methylbenzyl alcohol

Downstream raw materials:

1-benzyl-5-methylpyridin-2(1H)-one

N-benzyl-2-pyridone

1-(4-methylbenzyl)pyridin-2(1H)-one

5-methyl-1-(4-methylbenzyl)pyridin-2(1H)-one