2-(2,5-DIFLUORO-PHENYL)-PYRROLIDINE

Base Information

• Chemical Name: 2-(2,5-DIFLUORO-PHENYL)-PYRROLIDINE
• CAS No.: 886503-15-7
• Molecular Formula: C10H11F2N
• Molecular Weight: 183.201
• Mol file: 886503-15-7.mol

Synonyms:2-(2,5-Difluoro-phenyl)-pyrrolidine;2,6-DIMETHYL-3'-[8-(1,4-DIOXA-8-AZASPIRO[4.5]DECYL)METHYL]BENZOPHENONE;

Chemical Property of 2-(2,5-DIFLUORO-PHENYL)-PYRROLIDINE

Chemical Property:

• Boiling Point: 213.5±40.0 °C(Predicted)
• PKA: 9.02±0.10(Predicted)
• PSA: 12.03000
• Density: 1.164±0.06 g/cm3(Predicted)
• LogP: 2.71810
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

2-(2,5-Difluorophenyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2,5-DIFLUORO-PHENYL)-PYRROLIDINE

There total 12 articles about 2-(2,5-DIFLUORO-PHENYL)-PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole trifluoroacetatic acid → rac-2-(2,5-difluorophenyl)pyrrolidine (886503-15-7,1217630-38-0)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃;

Reference yield: 97.0%

5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole (1443623-92-4) → rac-2-(2,5-difluorophenyl)pyrrolidine (886503-15-7,1217630-38-0)

Guidance literature:

With methanol; sodium tetrahydroborate; water; at 5 - 25 ℃; for 2h;

Reference yield: 93.0%

1-pyrroline (5724-81-2) + 2-bromo-1,4-difluorobenzene (399-94-0) → rac-2-(2,5-difluorophenyl)pyrrolidine (886503-15-7,1217630-38-0)

Guidance literature:

2-bromo-1,4-difluorobenzene; With ethyl bromide; magnesium; In tetrahydrofuran; at 45 ℃; for 2.5h; Inert atmosphere;

1-pyrroline; In tetrahydrofuran; at 10 ℃; for 16h; Temperature; Inert atmosphere;

upstream raw materials:

5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole

2-bromo-1,4-difluorobenzene

tert-butyl 5-(2,5-difluorophenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

1-pyrroline

Downstream raw materials:

3-bromo-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid

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