399-94-0

Basic information

• Product Name: 1-Bromo-2,5-difluorobenzene
• Synonyms: 1,4-Difluoro-2-bromobenzene;2-BROMO-1,4-DIFLUOROBENZENE;2,5-DIFLUOROBROMOBENZENE;1-BROMO-2,5-DIFLUOROBENZENE;1-Bromo-2,5-difluorobenzene 98%;1-Bromo-2,5-difluorobenzene98%;1-BROMO-2,5-DIFLUOROBENZENE 99.5%;1-Bromo-2,5-difluoro
• CAS NO: 399-94-0
• Molecular Formula: C₆H₃BrF₂
• Molecular Weight: 192.99
• EINECS: 206-920-0
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Fluorobenzene;Miscellaneous;Bromine Compounds;Fluorine Compounds;Fluorobenzene Series;Aryl;C6;Halogenated Hydrocarbons;alkyl bromide| alkyl Fluorine
• Mol File: 399-94-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: −31 °C(lit.)
• Boiling Point: 58-59 °C20 mm Hg(lit.)
• Flash Point: 149 °F
• Appearance: Clear colourless liquid
• Density: 1.708 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000165mmHg at 25°C
• Refractive Index: n20/D 1.508(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Insoluble
• BRN: 1680893
• CAS DataBase Reference: 1-Bromo-2,5-difluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-2,5-difluorobenzene(399-94-0)
• EPA Substance Registry System: 1-Bromo-2,5-difluorobenzene(399-94-0)

Safety Data

• Hazard Codes: Xi,F,Xn
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-2637/39-37/39
• RIDADR: UN 2922
• WGK Germany: 3
• HazardClass: IRRITANT, FLAMMABLE
• Hazardous Substances Data: 399-94-0(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

2-Bromo-1,4-difluorobenzene has been used in the preparation of 1,4-difluoroanthraquinone, a precursor to ametantrone.

General Description

Lithiation of 2-bromo-1,4-difluorobenzene in the presence of lithium diisopropylamide (LDA) in THF-hexane, butyllithium in diethyl ether-hexane and butyllithium in THF-hexane has been reported.

InChI:InChI=1/C10H10O2/c11-10(12)9-6-8(9)7-4-2-1-3-5-7/h1-5,8-9H,6H2,(H,11,12)/t8-,9+/m0/s1

Upstream product

• 108-86-1 bromobenzene 
• 540-36-3 para-difluorobenzene 

Downstream Products

• 28736-42-7 1,4-difluoroanthracene-9,10-dione 
• 198967-26-9 2,5-difluoro-N-methoxy-N-methylbenzamide 
• 678982-63-3 (RS)-tert-butyl 4-[(2,5-difluorophenyl)-hydroxymethyl]-piperidine-1-carboxylate 
• 1443538-33-7 tert-butyl 5-(2,5-difluorophenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate 
• 1216260-42-2 4‐chloro‐1‐(2,5-difluorophenyl)butan-1-one 
• 899819-34-2 (2,5-difluorophenyl)magnesium bromide 
• 123942-11-0 4'-bromo-2 ',5'-difluoroacetophenone 

Relevant articles and documents

A 2, 5 - difluoro -4 - nitro benzoic acid (by machine translation)

The invention discloses a 2, 5 - difluoro - 4 - nitro-benzoic acid industrial preparation method. The 2, 5 - difluoro - 4 - nitro-benzoic acid industrial preparation method, the initial raw materials to the difluoro, through the bromo, nitration, carbonitriding, the hydrolysis of the four-step reaction synthesis of 2, 5 - difluoro - 4 - nitro-benzoic acid. The got in the course of 2, 5 - difluoro - 4 - nitrobenzoic acid as white powdery solid, purity 98.5%, each step the raw material conversion rate respectively reaches 100%, the total yield of the whole process 44.6%. (by machine translation)

Bromination of aromatic compounds using an Fe2O 3/zeolite catalyst

The catalytic bromination of non-activated aromatic compounds has been achieved using an Fe2O3/zeolite catalyst system. FeBr 3 was identified as the catalytic species, formed in situ from HBr and Fe2O3. The catalyst was easy-to-handle and cost effective and could also be recycled. The reaction system was also amenable to the one-pot sequential bromination/C-C bond formation of benzene.

Method for producing tetrakis ( fluoroaryl) borate-magnesium compound

Fluoroaryl magnesium halide is reacted with a boron compound so that a molar ratio of the fluoroaryl magnesium halide to the boron compound is not less than 3.0 and not more than 3.7, so as to produce a tetrakis (fluoroaryl) borate·magnesium compound. With this method, there occurs no hydrogen fluoride which corrodes a producing apparatus and requires troublesome waste water treatment.