(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methyl biphenyl-4-yl)hexanoic acid

Base Information

Chemical Name:(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methyl biphenyl-4-yl)hexanoic acid
CAS No.:230961-21-4
Molecular Formula:C35H44N2O5
Molecular Weight:572.73
Hs Code.:
UNII:W2WJ6ME4K7
ChEMBL ID:CHEMBL250266
Nikkaji Number:J1.977.168G
Pharos Ligand ID:ZZFXPBBCHS1L
Wikidata:Q76411501
Mol file:230961-21-4.mol

Synonyms:3-(((2,2-dimethyl-1-(((2-methoxy-1-phenylethyl)amino)carbonyl)propyl)amino)carbonyl)-6-(3-methyl-4-phenylphenyl)hexanoic acid;UK 370,106;UK 370106;UK-370,106;UK-370106;UK370,106;UK370106

Suppliers and Price of (R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methyl biphenyl-4-yl)hexanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
UK 370106
10mg
$ 516.00

TRC
UK370106
2.5mg
$ 215.00

Tocris
UK370106 ≥95%(HPLC)
10
$ 250.00

Medical Isotopes, Inc.
UK370106
5 mg
$ 625.00

Medical Isotopes, Inc.
UK370106
25 mg
$ 875.00

ChemScene
UK-370106 >99.0%
10mg
$ 800.00

ChemScene
UK-370106 >99.0%
1mg
$ 160.00

ChemScene
UK-370106 >99.0%
5mg
$ 470.00

ApexBio Technology
UK370106
10mg
$ 385.00

American Custom Chemicals Corporation
UK 370106 95.00%
5MG
$ 502.13

Total 8 raw suppliers

Chemical Property of (R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methyl biphenyl-4-yl)hexanoic acid

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:178-180 °C
Boiling Point:802.689°C at 760 mmHg
PKA:4.68±0.10(Predicted)
Flash Point:439.25°C
PSA：104.73000
Density:1.123g/cm³
LogP:6.89220
Storage Temp.:Store at +4°C
Solubility.:<57.27mg/ml in DMSO; <14.32mg/ml in ethanol
XLogP3:6.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:15
Exact Mass:572.32502251
Heavy Atom Count:42
Complexity:843

Purity/Quality:

≥95% by HPLC ^*data from raw suppliers

UK 370106 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=CC(=C1)CCCC(CC(=O)O)C(=O)NC(C(=O)NC(COC)C2=CC=CC=C2)C(C)(C)C)C3=CC=CC=C3
Isomeric SMILES:CC1=C(C=CC(=C1)CCC[C@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](COC)C2=CC=CC=C2)C(C)(C)C)C3=CC=CC=C3
Uses UK 370106 is a selective, insoluble MMP-3 inhibitor used for the topical treatment of chronic dermal ulcers and wound healing wafers.

Technology Process of (R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methyl biphenyl-4-yl)hexanoic acid

There total 26 articles about (R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methyl biphenyl-4-yl)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5002-26-6
3-methyl-4-phenylbromobenzene

: 230961-21-4
UK-370106

Guidance literature:: Multi-step reaction with 8 steps

1.1: Mg; I₂ / tetrahydrofuran / Heating

1.2: 60 percent / tetrahydrofuran / -40 - 0 °C

2.1: Et₃SiH; TFA / 0 - 20 °C

3.1: (COCl)2; DMF / CH₂Cl₂ / -10 - 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -70 - -50 °C

4.2: 91 percent / tetrahydrofuran; hexane / -70 - 0 °C

5.1: NaN(SiMe₃)2 / tetrahydrofuran / 1 h / -75 °C

5.2: 61 percent / tetrahydrofuran / -70 - -50 °C

6.1: 97 percent / aq. H₂O₂; LiOH / tetrahydrofuran / 0 - 20 °C

7.1: 99 percent / N-(dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; i-Pr₂NEt; 1-hydroxy-1,2,3-benzotriazole hydrate / CH₂Cl₂ / 4 - 20 °C

8.1: 80 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

With triethylsilane; lithium hydroxide; n-butyllithium; oxalyl dichloride; dihydrogen peroxide; iodine; sodium hexamethyldisilazane; magnesium; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm0308038

Reference yield:

: 116632-39-4
2-methyl-4-bromoiodobenzene

: 230961-21-4
UK-370106

Guidance literature:: Multi-step reaction with 9 steps

1.1: 79 percent / Pd(OAc)2; PPh₃; aq. Na₂CO₃ / acetone / 18 h / Heating

2.1: Mg; I₂ / tetrahydrofuran / Heating

2.2: 60 percent / tetrahydrofuran / -40 - 0 °C

3.1: Et₃SiH; TFA / 0 - 20 °C

4.1: (COCl)2; DMF / CH₂Cl₂ / -10 - 20 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -70 - -50 °C

5.2: 91 percent / tetrahydrofuran; hexane / -70 - 0 °C

6.1: NaN(SiMe₃)2 / tetrahydrofuran / 1 h / -75 °C

6.2: 61 percent / tetrahydrofuran / -70 - -50 °C

7.1: 97 percent / aq. H₂O₂; LiOH / tetrahydrofuran / 0 - 20 °C

8.1: 99 percent / N-(dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; i-Pr₂NEt; 1-hydroxy-1,2,3-benzotriazole hydrate / CH₂Cl₂ / 4 - 20 °C

9.1: 80 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

With triethylsilane; palladium diacetate; lithium hydroxide; n-butyllithium; oxalyl dichloride; dihydrogen peroxide; iodine; sodium hexamethyldisilazane; sodium carbonate; magnesium; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; acetone; 1.1: Suzuki reaction;
DOI:10.1021/jm0308038

Reference yield:

: 91298-74-7
(S)-2-methoxy-1-phenylethylamine

: 230961-21-4
UK-370106

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / N-(dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; N-methylmorpholine; 1-hydroxy-1,2,3-benzotriazole hydrate / CH₂Cl₂ / 2 - 20 °C

2: 97 percent / HCl(gas) / CH₂Cl₂; dioxane / 4 - 20 °C

3: 99 percent / N-(dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; i-Pr₂NEt; 1-hydroxy-1,2,3-benzotriazole hydrate / CH₂Cl₂ / 4 - 20 °C

4: 80 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm0308038