5002-26-6

Basic information

• Product Name: 4-BROMO-2-METHYLBIPHENYL
• Synonyms: 4-BROMO-2-METHYLBIPHENYL;4-bromo-2-methyl-1,1'-Biphenyl
• CAS NO: 5002-26-6
• Molecular Formula: C₁₃H₁₁Br
• Molecular Weight: 247.13
• EINECS: -0
• Mol File: 5002-26-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 113-114°C 0,7mm
• Flash Point: 113-114°C/0.7mm
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.6210
• BRN: 1908937
• CAS DataBase Reference: 4-BROMO-2-METHYLBIPHENYL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-METHYLBIPHENYL(5002-26-6)
• EPA Substance Registry System: 4-BROMO-2-METHYLBIPHENYL(5002-26-6)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 5002-26-6(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-methylbiphenyl is a synthetic organic compound with an aromatic nature, given its biphenyl structure. 4-BROMO-2-METHYLBIPHENYL is characterized by the molecular formula C13H11Br. It consists of two phenyl rings bonded together, with a bromine attached to the fourth carbon atom and a methyl group attached to the second carbon atom in one of the phenyl rings. 4-BROMO-2-METHYLBIPHENYL demonstrates significant reactivity, typical of aryl bromides, making it a useful reagent in various chemical syntheses. It may pose some health hazards upon exposure, as it can potentially cause skin and eye irritations in direct contact situations. 4-BROMO-2-METHYLBIPHENYL has widespread usage in chemical and pharmaceutical industries.

InChI:InChI=1/C13H11Br/c1-10-9-12(14)7-8-13(10)11-5-3-2-4-6-11/h2-9H,1H3

Upstream product

• 116632-39-4 2-methyl-4-bromoiodobenzene 
• 100-59-4 phenylmagnesium chloride 
• 583-75-5 4-Bromo-2-methylaniline 
• 98-80-6 phenylboronic acid 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 71-43-2 benzene 

Downstream Products

• 230962-03-5 tert-butyl (3R,5E)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-[(3-methyl-4-phenyl)phenyl]hex-5-enoate 
• 414869-76-4 (R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)pentanoic acid cyclohexylammonium salt 
• 414869-73-1 (E)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)-2-pentenoic acid cyclohexylammonium salt 
• 230961-33-8 N₁-[(1S)-2,2-dimethyl-1-([((1R)-1-(3-pyridyl)ethyl)amino]carbonyl)propyl]-(N₄-hydroxy)-(2R)-2-{3-[3-methyl-(4-phenyl)phenyl]propyl}butanediamide 

Relevant articles and documents

Palladium-catalyzed cross-coupling of aryldiazonium tetrafluoroborate salts with arylboronic esters

A novel palladium-catalyzed reaction of aryldiazonium tetrafluoroborate salts with arylboronic esters furnishes cross-coupled products in moderate yields. The reaction proceeds at relatively mild temperatures and in aqueous media. (C) 2000 Published by Elsevier Science Ltd.

Asymmetric synthesis of an MMP-3 inhibitor incorporating a 2-alkyl succinate motif

An efficient and practical synthesis is presented of the pharmaceutically active MMP-3 inhibitor UK-370,106 (1) via an olefination/catalytic asymmetric hydrogenation sequence. Commercially available 5-bromo-2-iodotoluene was converted in two steps to the

Matrix metalloprotease inhibitors

Compounds of formula (I): or pharmaceutically acceptable salts thereof, or solvates of either entity, wherein the substituents have the values described herein, are useful as matrix metalloprotease (MMP) inhibitors