2-Bromo-1-iodo-4-methoxybenzene

Base Information

• Chemical Name: 2-Bromo-1-iodo-4-methoxybenzene
• CAS No.: 466639-53-2
• Molecular Formula: C7H6BrIO
• Molecular Weight: 312.933
• Hs Code.: 2909309090
• Mol file: 466639-53-2.mol

Synonyms:2-bromo-1-iodo-4-methoxybenzene; 3-Bromo-4-iodophenyl methyl ether; Benzene, 2-bromo-1-iodo-4-methoxy-

Chemical Property of 2-Bromo-1-iodo-4-methoxybenzene

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.65
• Boiling Point: 284.87°C at 760 mmHg
• Flash Point: 126.085°C
• PSA: 9.23000
• Density: 2.063g/cm³
• LogP: 3.06230
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-1-iodo-4-methoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): IRRITANT
• Hazard Codes: IRRITANT

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-1-iodo-4-methoxybenzene

There total 9 articles about 2-Bromo-1-iodo-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-methoxyphenyl bromide (2398-37-0) → 3-bromo-4-iodoanisole (466639-53-2)

Guidance literature:

With iodine; acetic anhydride; mercury(II) oxide; In dichloromethane; for 14.5h; regiospecific reaction; Reflux;

DOI:10.1016/j.ejmech.2010.05.007

Reference yield: 17.0%

→ 3-bromo-4-iodoanisole (466639-53-2)

Guidance literature:

Reference yield:

3-methoxyphenyl bromide (2398-37-0) → 3-bromo-4-iodoanisole (466639-53-2) + 4-bromo-1-iodo-2-methoxybenzene (791642-68-7)

Guidance literature:

With N-iodo-succinimide; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); In dichloromethane; toluene; at 40 ℃; for 14h; Overall yield = 98 %; regioselective reaction;

DOI:10.1055/s-0033-1340321

upstream raw materials:

3-methoxyphenyl bromide

4-nitro-phenol

p-nitrophenyl methanesulfonate

methanesulfonic acid 4-aminophenyl ester

Downstream raw materials:

tert-butyl 6-methoxyindoline-1-carboxylate

tert-butyl 6-methoxy-7-(4-methoxyphenyl)indoline-1-carboxylate

tert-butyl 6-methoxy-7-(4-(trifluoromethyl)phenyl)indoline-1-carboxylate

tert-butyl 7-(4-bromophenyl)-6-methoxyindoline-1-carboxylate

Refernces

• 1、 Doan, Thu-Hong,Chardon, Aurélien,Osi, Arnaud,Mahaut, Damien,Tumanov, Nikolay,Wouters, Johan,Champagne, Beno?t,Berionni, Guillaume. "Methylene Bridging Effect on the Structures, Lewis Acidities and Optical Properties of Semi-planar Triarylboranes". supporting information. p. 1736 - 1743. Retrieved 2020/12/11.
• 2、 Yoshioka, Shohei,Fujii, Yuki,Tsujino, Hirofumi,Uno, Tadayuki,Fujioka, Hiromichi,Arisawa, Mitsuhiro. "One-pot enyne metathesis/Diels-Alder/oxidation to six-membered silacycles with a multi-ring core: Discovery of novel fluorophores". supporting information. p. 5970 - 5973. Retrieved 2017/07/10.