3-Oxa-8-azabicyclo[3.2.1]octane

Base Information

Chemical Name:3-Oxa-8-azabicyclo[3.2.1]octane
CAS No.:280-07-9
Molecular Formula:C6H11NO
Molecular Weight:113.159
Hs Code.:2934999090
DSSTox Substance ID:DTXSID20570351
Nikkaji Number:J2.993.466E
Mol file:280-07-9.mol

Synonyms:3-oxa-8-azabicyclo[3.2.1]octane;280-07-9;3-OXA-8-AZA-BICYCLO[3.2.1]OCTANE;SCHEMBL55587;DTXSID20570351;MNILDQSRDHCFJG-UHFFFAOYSA-N;MFCD18250273;AKOS006350951;SB19955;DS-17600;CS-0054659;EN300-82710;P12236;F2147-2297

Suppliers and Price of 3-Oxa-8-azabicyclo[3.2.1]octane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Synthonix
3-Oxa-8-azabicyclo[3.2.1]octane 95+%
10g
$ 3900.00

Matrix Scientific
3-Oxa-8-azabicyclo[3.2.1]octane 95+%
1g
$ 1304.00

J&W Pharmlab
3-Oxa-8-aza-bicyclo[3.2.1]octane 96%
1g
$ 50.00

J&W Pharmlab
3-Oxa-8-aza-bicyclo[3.2.1]octane 96%
25g
$ 720.00

J&W Pharmlab
3-Oxa-8-aza-bicyclo[3.2.1]octane 96%
5g
$ 190.00

Crysdot
3-Oxa-8-azabicyclo[3.2.1]octane 95+%
250mg
$ 178.00

Crysdot
3-Oxa-8-azabicyclo[3.2.1]octane 95+%
100mg
$ 112.00

Crysdot
3-Oxa-8-azabicyclo[3.2.1]octane 95+%
1g
$ 446.00

Chemenu
3-Oxa-8-azabicyclo[3.2.1]octane 95%
1g
$ 421.00

American Custom Chemicals Corporation
3-OXA-8-AZA-BICYCLO[3.2.1]OCTANE 95.00%
5MG
$ 505.16

Total 21 raw suppliers

Chemical Property of 3-Oxa-8-azabicyclo[3.2.1]octane

Chemical Property:

Boiling Point:176.6±15.0 °C(Predicted)
PKA:9.14±0.20(Predicted)
PSA：21.26000
Density:1.028±0.06 g/cm3(Predicted)
LogP:0.46600
XLogP3:0
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:113.084063974
Heavy Atom Count:8
Complexity:84.5

Purity/Quality:

97% ^*data from raw suppliers

3-Oxa-8-azabicyclo[3.2.1]octane 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2COCC1N2
Uses 3-Oxa-8-azabicyclo[3.2.1]octane is used for the development of PI3K inhibitors.

Technology Process of 3-Oxa-8-azabicyclo[3.2.1]octane

There total 1 articles about 3-Oxa-8-azabicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 280-07-9
3-oxa-8-aza-bicyclo[3.2.1]octane

Guidance literature:: With sulfuric acid;

Reference yield: 100.0%

: 280-07-9
3-oxa-8-aza-bicyclo[3.2.1]octane

: 1-(3'-carboxy-2'-fluoro-biphenyl-3-yl)-5-cyclopropyl-1H-pyrazole-4-carboxylic acid methyl ester

: 5-cyclopropyl-1-[3-(2-fluoro-3-{3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl}phenyl)phenyl]-1H-pyrazole-4-carboxylic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; for 4h;

Reference yield: 30.0%

: 280-07-9
3-oxa-8-aza-bicyclo[3.2.1]octane

: (1S,5S,6S)-3-((tert-butoxycarbonyl)amino)-5-(5-((Z)-2-(5-cyanopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxylic acid

: 6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile

Guidance literature:: (1S,5S,6S)-3-((tert-butoxycarbonyl)amino)-5-(5-((Z)-2-(5-cyanopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxylic acid; With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In acetonitrile; at 20 ℃; for 0.166667h;

3-oxa-8-aza-bicyclo[3.2.1]octane; In acetonitrile; for 0.5h;

With hydrogenchloride; In methanol; water; acetonitrile; at 60 ℃; for 0.5h;