4-(2-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-4-(4-chlorophenyl)thiazol-5-yl)benzenesulfonamide

Base Information

Chemical Name:4-(2-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-4-(4-chlorophenyl)thiazol-5-yl)benzenesulfonamide
CAS No.:1454649-80-9
Molecular Formula:C₂₂H₂₀ClN₃O₄S₂
Molecular Weight:490.003
Hs Code.:

Synonyms:4-(2-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-4-(4-chlorophenyl)thiazol-5-yl)benzenesulfonamide

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Chemical Property of 4-(2-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-4-(4-chlorophenyl)thiazol-5-yl)benzenesulfonamide

Chemical Property:

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Technology Process of 4-(2-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-4-(4-chlorophenyl)thiazol-5-yl)benzenesulfonamide

There total 4 articles about 4-(2-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-4-(4-chlorophenyl)thiazol-5-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.3%

: 1454650-25-9
3-oxa-8-azabicyclo[3.2.1]octan-8-yl(5-bromo-4-(4-chlorophenyl)thiazol-2-yl)methanone

: 613660-87-0
4-sulfamoylphenylboronic acid

: 1454649-80-9
4-(2-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-4-(4-chlorophenyl)thiazol-5-yl)benzenesulfonamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 90 - 95 ℃; for 18h; Inert atmosphere; Sealed tube;

Reference yield:

: 1454650-23-7
3-oxa-8-azabicyclo[3.2.1]octan-8-yl(4-bromothiazol-2-yl)methanone

: 1454649-80-9
4-(2-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-4-(4-chlorophenyl)thiazol-5-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 18 h / 90 - 95 °C / Inert atmosphere; Sealed tube

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 4 h / 50 - 55 °C

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 18 h / 90 - 95 °C / Inert atmosphere; Sealed tube

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1454650-24-8
3-oxa-8-azabicyclo[3.2.1]octan-8-yl(4-(4-chlorophenyl)thiazol-2-yl)methanone

: 1454649-80-9
4-(2-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-4-(4-chlorophenyl)thiazol-5-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 4 h / 50 - 55 °C

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 18 h / 90 - 95 °C / Inert atmosphere; Sealed tube

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; N,N-dimethyl-formamide; toluene;