Azithromycin N-Oxide

Base Information

• Chemical Name: Azithromycin N-Oxide
• CAS No.: 90503-06-3
• Molecular Formula: C38H72N2O13
• Molecular Weight: 764.98.
• Hs Code.: 2934990002
• Mol file: 90503-06-3.mol

Synonyms:Azithromycin N-Oxide (15 mg);(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-

Chemical Property of Azithromycin N-Oxide

Chemical Property:

• PKA: 12.51±0.60(Predicted)
• PSA: 206.27000
• LogP: 1.87210

Purity/Quality:

NLT 98% ^*data from raw suppliers

Azithromycin N-oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Azithromycin N-Oxide

There total 2 articles about Azithromycin N-Oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Zithromax(R) (83905-01-5,92470-27-4) → azithromycin-3'-N-oxide (90503-06-3)

Guidance literature:

With dihydrogen peroxide; In water; acetone; at 20 ℃; for 3.5h;

Reference yield: 78.0%

Zithromax(R) (83905-01-5,92470-27-4) → azithromycin-3'-N-oxide (90503-06-3) + C38H72N2O14

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 20 ℃; for 4h;

Reference yield:

azithromycin-3'-N-oxide (90503-06-3) → (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)‐2‐ethyl‐3,4,10‐trihydroxy‐13‐{(2R,4R,5S,6S)‐5‐hydroxy‐4‐methoxy‐4,6‐dimethyl-tetrahydropyran‐2‐yloxy}‐11‐{(2S,3R,4S,6R)‐3‐hydroxy‐6‐methyl‐4‐methylamino-tetrahydropyran‐2‐yloxy}‐3,5,6,8,10,12,14‐heptamethyl‐1‐oxa‐6‐azacyclopentadecan‐15‐one (172617-84-4)

Guidance literature:

With sodium hydrogencarbonate; N-fluorobis(benzenesulfon)imide; In dichloromethane; at 30 ℃; for 24h; Solvent;

upstream raw materials:

Zithromax(R)

Downstream raw materials:

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)‐2‐ethyl‐3,4,10‐trihydroxy‐13‐{(2R,4R,5S,6S)‐5‐hydroxy‐4‐methoxy‐4,6‐dimethyl-tetrahydropyran‐2‐yloxy}‐11‐{(2S,3R,4S,6R)‐3‐hydroxy‐6‐methyl‐4‐methylamino-tetrahydropyran‐2‐yloxy}‐3,5,6,8,10,12,14‐heptamethyl‐1‐oxa‐6‐azacyclopentadecan‐15‐one

Refernces

• 1、 -. "Derivatives of azithromycin". Page/Page column 5. . Retrieved 2008/06/13.
• 2、 -. "9A-AZALIDES WITH ANTI-INFLAMMATORY ACTIVITY". Page 27. . Retrieved 2008/06/13.