172617-84-4

Basic information

• Product Name: N'-DesMethyl AzithroMycin
• Synonyms: (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptaMethyl-11-[[3,4,6-trideoxy-3-(MethylaMino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one;CP-64434;N-DesMethyl AzithroMycin (IMpurity I);3′-N-Desmethylazithromycin;N-Demethylazithromycin;CP-64434 hydrate;N′-Desmethylazithromycin hydrate;Azithromycin EP Impurity I (N-Desmethyl Azithromycin)
• CAS NO: 172617-84-4
• Molecular Formula: C₃₇H₇₀N₂O₁₂
• Molecular Weight: 734.9579
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 172617-84-4.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 821.4±65.0 °C(Predicted)
• Appearance: white to off-white/
• Density: 1.18±0.1 g/cm3(Predicted)
• Storage Temp.: room temp
• Solubility: DMSO: ≥10mg/mL
• PKA: 13.28±0.70(Predicted)
• CAS DataBase Reference: N'-DesMethyl AzithroMycin(CAS DataBase Reference)
• NIST Chemistry Reference: N'-DesMethyl AzithroMycin(172617-84-4)
• EPA Substance Registry System: N'-DesMethyl AzithroMycin(172617-84-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 172617-84-4(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 172617-84-4 differently. You can refer to the following data:
1. N’-Desmethyl Azithromycin (Azithromycin EP Impurity I) is a metabolite of Azithromycin (A927000) as potential anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agent.
2. A metabolite of Azithromycin (A927000) as potential anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agent.

Upstream product

• 90503-06-3 azithromycin-3'-N-oxide 
• 83905-01-5 Zithromax(R) 

Downstream Products

• 957063-68-2 3'-N-demethyl-3'-N-benzyloxycarbonyl-9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A 
• 612069-31-5 N-[(2S,3R,4S,6R)-2-[[(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacyclopentadec-11-yl]oxy]-3-hydroxy-6-methyltetrahydropyran-4-yl]-N,4-dimethylbenzenesulfonamide 
• 957063-17-1 (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-[benzyl(methyl)amino]-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one 
• 1307759-43-8 3'-N-(benzylthiocarbamoyl)-3'-N-demethyl-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A 
• 1236116-85-0 C₄₄H₇₅N₃O₁₄ 
• 1236116-08-7 N-3'-p-bromobenzyl-N-3'-desmethylazithromycin 
• 1192304-11-2 N'-benzyl-2'-O,3'-N-(carbonimidoyl)-3'-N-demethyl-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A 
• 1192304-52-1 2'-O,3'-N-(carbonimidoyl)-3'-N-demethyl-N'-[4-(metoxy)phenyl]-9a-methyl-9a-aza-9a-homoerythromycin A 
• 1093856-81-5 (3'-N-(4-ethynylbenzyl))azithromycin 
• 1093857-05-6 C₅₃H₉₁N₃O₁₅ 
• 677726-24-8 C₄₁H₇₄N₂O₁₂ 

Relevant articles and documents

ANTI-INFECTIVE AND ANTI-VIRAL COMPOUNDS AND COMPOSITIONS

Lysosomally accumulated substances that release a nitroxy group, or a short chain fatty acid or a product of anaerobic metabolism or a thiol or a sulfide often from an ester or similar labile linkage have anti-inflammatory, anti-cancer and anti-bacterial activity. They are useful in treating infectious, inflammatory and malignant disease and are immune stimulatory, promote zinc uptake, disable endosomal reactions and synergise anti-viral action of protease inhibitors. The compounds are useful for the treatment of bacterial, viral and mixed pneumonias.

TRIAZOLE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME

The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.

Macrocyclic lactone impurity synthetic method

The invention relates to a method for preparing an azithromycin impurity I and an azithromycin impurity E. The method comprises the following steps: mixing azithromycin with a solvent, and adding the mixture into a compound which is shown as (I) in the description to perform a demethylation reaction, wherein R1 and R2 are respectively and independently methyl, ethyl, propyl, naphthenic group, a phenyl and p-methylphenyl. According to the method for preparing azithromycin impurity, the reaction is carried out under a mild condition; the method can be used for preparing the azithromycin impurity I and the azithromycin impurity E by controlling the amount of a reagent; the HPLC purity of the azithromycin impurities prepared by the method is 98 percent or more.