3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

Base Information

• Chemical Name: 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
• CAS No.: 545445-44-1
• Molecular Formula: C20H25N3O3
• Molecular Weight: 355.437
• Hs Code.: 2934999090
• Mol file: 545445-44-1.mol

Synonyms:3-Morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-5,6-dihydro-1H-pyridin-2-one;

Chemical Property of 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

Chemical Property:

• Boiling Point: 624.979 °C at 760 mmHg
• PKA: 3.25±0.20(Predicted)
• Flash Point: 331.775 °C
• PSA: 53.09000
• Density: 1.267 g/cm³
• LogP: 2.22420
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%min ^*data from raw suppliers

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropy can be used as an organic synthesis intermediate, mainly used in laboratory research and development and chemical production processes.

Technology Process of 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

There total 48 articles about 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

morpholine (110-91-8,99108-56-2) + 1-(piperidin-2-one-1-yl)-4-(5,6-dihydro-3-chloropyridine-2(1H)-one-1-yl)benzene → 5,6?dihydro?3?(4?morpholinyl)?1?[4?(2?oxo?1?piperidinyl)phenyl]?2(1H)?pyridone (545445-44-1)

Guidance literature:

1-(piperidin-2-one-1-yl)-4-(5,6-dihydro-3-chloropyridine-2(1H)-one-1-yl)benzene; With bromine; sodium hydroxide; In dichloromethane; water; at 25 - 35 ℃; for 4h;

morpholine; With triethylamine; In N,N-dimethyl-formamide; at 95 - 100 ℃; for 5h; Reagent/catalyst; Solvent; Temperature;

Reference yield: 94.27%

5-Chlorovaleroyl chloride (1575-61-7) + 1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one (1267610-26-3) → 5,6?dihydro?3?(4?morpholinyl)?1?[4?(2?oxo?1?piperidinyl)phenyl]?2(1H)?pyridone (545445-44-1)

Guidance literature:

5-Chlorovaleroyl chloride; 1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one; With tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; water; at 0 - 5 ℃; for 1h;

With potassium hydroxide; In dichloromethane; water; at 20 ℃; Reagent/catalyst; Solvent; Temperature;

Reference yield: 93.1%

piperidin-2-one (675-20-7) + 1-(4-chlorophenyl)-3-morpholine-5,6-dihydropyridine-2(1H)-one → 5,6?dihydro?3?(4?morpholinyl)?1?[4?(2?oxo?1?piperidinyl)phenyl]?2(1H)?pyridone (545445-44-1)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 2h; Solvent;

upstream raw materials:

1-(4-iodo-phenyl)-3-morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one

piperidin-2-one

1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one

5-chloropentanoic acid [4-(5-morpholin-4-yl-6-oxo-3,6-dihydro-2H-pyridin-1-yl)phenyl]amide

Downstream raw materials:

1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester

1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid

1-(4-benzyloxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester

Refernces

• 1、 -. "Preparation method of dihydropyridone derivatives". Paragraph 0059-0063; 0069; 0073-0077; 0082-0086; 0091-0095. . Retrieved 2020/05/30.
• 2、 -. "Preparation method of 5,6-dihydropyridine-2 (1H)-one derivative". . . Retrieved 2020/06/17.