14-O-Acetyl Noroxycodone Hydrochloride

Base Information

• Chemical Name: 14-O-Acetyl Noroxycodone Hydrochloride
• CAS No.: 70866-63-6
• Molecular Formula: C19H22ClNO5
• Molecular Weight: 379.84
• Mol file: 70866-63-6.mol

Synonyms:14-Acetylnoroxycodone;(5|A)-14-(Acetyloxy)-4,5-epoxy-3-methoxy-morphinan-6-one Hydrochloride;14-Acetoxy-7,8-dihydronorcodeinone Hydrochloride;14-O-Acetyl Noroxycodone Hydrochloride;

Chemical Property of 14-O-Acetyl Noroxycodone Hydrochloride

Chemical Property:

• PSA: 73.86000
• LogP: 2.40760

Purity/Quality:

14-O-Acetyl noroxycodone hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Protected derivative of an Oxycodone metabolite.

Technology Process of 14-O-Acetyl Noroxycodone Hydrochloride

There total 2 articles about 14-O-Acetyl Noroxycodone Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

14-acetoxy-4,5α-epoxy-3-methoxy-17-methylmorphinan-6-one (70509-92-1) → C19H21NO5*ClH (70866-63-6)

Guidance literature:

With carbonochloridic acid 1-chloro-ethyl ester;

DOI:10.1021/jo00185a072

Reference yield:

Oxycodone (76-42-6) → C19H21NO5*ClH (70866-63-6)

Guidance literature:

Multi-step reaction with 2 steps

2: α-chloroethyl chloroformate

With carbonochloridic acid 1-chloro-ethyl ester;

DOI:10.1021/jo00185a072

Reference yield:

C19H21NO5*ClH (70866-63-6) → noroxycodone (57664-96-7)

Guidance literature:

With hydrogenchloride; In water; Yield given;

DOI:10.1021/jo00185a072

upstream raw materials:

14-acetoxy-4,5α-epoxy-3-methoxy-17-methylmorphinan-6-one

Oxycodone

Downstream raw materials:

noroxycodone

naltrexone methyl ether