Tosyl-propargyl-triethylene glycol

Base Information

• Chemical Name: Tosyl-propargyl-triethylene glycol
• CAS No.: 888009-94-7
• Molecular Formula: C16H22O6S
• Molecular Weight: 342.413
• Mol file: 888009-94-7.mol

Synonyms:Toluene-4-sulfonic acid 2-[2-(2-prop-2-ynyloxy-ethoxy)-ethoxy]-ethyl ester; Ethanol, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 1-(4-methylbenzenesulfonate);Tosyl-propargyl-triethylene glycole; Ethanol, 2-[2-[2-(2-propynyloxy)ethoxy]ethoxy]-, 4-methylbenzenesulfonate; TPTG;

Chemical Property of Tosyl-propargyl-triethylene glycol

Chemical Property:

• Appearance/Colour: Colorless oil

Purity/Quality:

99% ^*data from raw suppliers

2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl4-methylbenzenesulfonate 95%-98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Tosyl-propargyl-triethylene glycol

There total 4 articles about Tosyl-propargyl-triethylene glycol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-toluenesulfonyl chloride (98-59-9) + O-propargyl triethylene glycol (208827-90-1) → 2-[2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy]ethyl 4-methylbenzene-1-sulfonate (888009-94-7)

Guidance literature:

With triethylamine;

DOI:10.1016/j.bmcl.2009.01.028

Reference yield: 46.2%

→ 2-[2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy]ethyl 4-methylbenzene-1-sulfonate (888009-94-7)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 25 ℃; for 19.0833h; Inert atmosphere;

Reference yield:

propargyl alcohol (107-19-7) + triethylene glycol di-(p-toluenesulfonate) (19249-03-7) → 2-[2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy]ethyl 4-methylbenzene-1-sulfonate (888009-94-7)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2009.08.091

upstream raw materials:

p-toluenesulfonyl chloride

O-propargyl triethylene glycol

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

propargyl alcohol

Downstream raw materials:

2-[2-(2-{2-[4-({2-[2-(2-{4-[(2-{2-[2-(4-methylbenzenesulfonyl)ethoxy]ethoxy}ethoxy)methyl]-1H-1,2,3-triazol-1-yl}ethoxy)ethoxy]ethoxy}methyl)-1H-1,2,3-triazol-1-yl]ethoxy}ethoxy)ethyl]isoindoline-1,3-dione

C₄₈H₆₈N₁₀O₁₆S

2-{2-[2-(2-{4-[(2-{2-[2-(4-methylbenzenesulfonyl)ethoxy]ethoxy}ethoxy)methyl]-1H-1,2,3-triazol-1-yl}ethoxy)ethoxy]ethyl}isoindoline-1,3-dione

C₁₈H₂₄O₆