6-Bromo-2-methylpyridine-3-carboxaldehyde

Base Information

• Chemical Name: 6-Bromo-2-methylpyridine-3-carboxaldehyde
• CAS No.: 926293-55-2
• Molecular Formula: C7H6BrNO
• Molecular Weight: 200.035
• Hs Code.: 2933399090
• Mol file: 926293-55-2.mol

Synonyms:6-bromo-2-methylpyridine-3-carbaldehyde

Chemical Property of 6-Bromo-2-methylpyridine-3-carboxaldehyde

Chemical Property:

• Boiling Point: 285 oC
• Flash Point: 126 oC
• PSA: 29.96000
• Density: 1.577
• LogP: 1.96500
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromo-2-methylnicotinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromo-2-methylpyridine-3-carboxaldehyde

There total 1 articles about 6-Bromo-2-methylpyridine-3-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2,5-dibromo-6-methylpyridine (39919-65-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-bromo-2-methylpyridine-3-carboxaldehyde (926293-55-2)

Guidance literature:

2,5-dibromo-6-methylpyridine; With n-butyllithium; In hexanes; diethyl ether; at -78 ℃; for 1h;

N,N-dimethyl-formamide; In hexanes; diethyl ether; at -78 - 20 ℃; for 2h;

Reference yield: 84.0%

4-Methoxybenzenethiol (696-63-9) + 6-bromo-2-methylpyridine-3-carboxaldehyde (926293-55-2) → 6-(4-methoxy-phenylsulfanyl)-2-methyl-pyridine-3-carbaldehyde (926305-06-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield: 80.0%

6-bromo-2-methylpyridine-3-carboxaldehyde (926293-55-2) + 4-methoxy-phenol (150-76-5) → 6-(4-methoxy-phenoxy)-2-methyl-pyridine-3-carbaldehyde (926305-05-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 1h;

upstream raw materials:

2,5-dibromo-6-methylpyridine

N,N-dimethyl-formamide

Downstream raw materials:

C₁₄H₁₁NO₃S

6-(4-methoxy-phenoxy)-2-methyl-pyridine-3-carbaldehyde

6-(4-methoxy-phenylsulfanyl)-2-methyl-pyridine-3-carbaldehyde

6-(4-bromo-3-methyl-phenoxy)-2-methyl-pyridine-3-carbaldehyde

Refernces

• 1、 -. "Protein kinase inhibitor and its preparation method and medical application". Paragraph 0310-0313. . Retrieved 2017/05/26.
• 2、 -. "CHEMOKINE RECEPTOR BINDING COMPOUNDS". Page/Page column 51. . Retrieved 2010/11/26.