2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine

Base Information

• Chemical Name: 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine
• CAS No.: 934524-10-4
• Molecular Formula: C13H9Cl2N3O2S
• Molecular Weight: 342.205
• Hs Code.: 2933990090
• Mol file: 934524-10-4.mol

Synonyms:2,4-Dichloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine;

Chemical Property of 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.707
• Boiling Point: 447.131 °C at 760 mmHg
• PKA: 0.47±0.30(Predicted)
• Flash Point: 224.217 °C
• PSA: 73.23000
• Density: 1.594 g/cm³
• LogP: 4.36430
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine

There total 7 articles about 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

toluene-4-sulfonic acid (104-15-4) + 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (90213-66-4) → 2,4-dichloro-7-p-methylbenzenesulfonyl-7H-pyrrole[2,3-d]pyrimidin-4-amine (934524-10-4)

Guidance literature:

2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

toluene-4-sulfonic acid; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield: 99.0%

p-toluenesulfonyl chloride (98-59-9) + 2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine (63200-54-4) → 2,4-dichloro-7-p-methylbenzenesulfonyl-7H-pyrrole[2,3-d]pyrimidin-4-amine (934524-10-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield: 97.0%

2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (90213-66-4) + p-toluenesulfonyl chloride (98-59-9) → 2,4-dichloro-7-p-methylbenzenesulfonyl-7H-pyrrole[2,3-d]pyrimidin-4-amine (934524-10-4)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; at 18 - 25 ℃; for 0.5h;

upstream raw materials:

4-chloro-7-[(4-methylbenzene)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine

2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

p-toluenesulfonyl chloride

toluene-4-sulfonic acid

Downstream raw materials:

2-chloro-7-tosyl-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

7-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-2,3-dihydro-1H-isoindol-1-one

2-bromo-6-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)benzoic acid

2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)benzoic acid