4-chloro-7-[(4-methylbenzene)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Base Information

• Chemical Name: 4-chloro-7-[(4-methylbenzene)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine
• CAS No.: 934524-13-7
• Molecular Formula: C₁₃H₁₁ClN₄O₂S
• Molecular Weight: 322.775
• Mol file: 934524-13-7.mol

Synonyms:4-chloro-7-[(4-methylbenzene)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Chemical Property of 4-chloro-7-[(4-methylbenzene)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Chemical Property:

Purity/Quality:

≥98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-7-[(4-methylbenzene)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine

There total 2 articles about 4-chloro-7-[(4-methylbenzene)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine (84955-31-7) + p-toluenesulfonyl chloride (98-59-9) → 4-chloro-7-[(4-methylbenzene)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine (934524-13-7)

Guidance literature:

4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

p-toluenesulfonyl chloride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 2h;

Reference yield:

2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (7355-55-7) → 4-chloro-7-[(4-methylbenzene)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine (934524-13-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trichlorophosphate / 5 h / 110 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 2 h / 0 °C

With sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

4-chloro-7-[(4-methylbenzene)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine (934524-13-7) → 2,4-dichloro-7-p-methylbenzenesulfonyl-7H-pyrrole[2,3-d]pyrimidin-4-amine (934524-10-4)

Guidance literature:

4-chloro-7-[(4-methylbenzene)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine; With chloro-trimethyl-silane; tert.-butylnitrite; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; at 20 ℃; for 0.583333h;

With water; In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine

p-toluenesulfonyl chloride

2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Downstream raw materials:

2,4-dichloro-7-p-methylbenzenesulfonyl-7H-pyrrole[2,3-d]pyrimidin-4-amine

4-chloro-2-iodo-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine