5-fluoro-6-bromonicotinc acid

Base Information

• Chemical Name: 5-fluoro-6-bromonicotinc acid
• CAS No.: 38186-87-7
• Molecular Formula: C6H3BrFNO2
• Molecular Weight: 220
• Hs Code.: 2933399090
• Mol file: 38186-87-7.mol

Synonyms:6-Bromo-5-fluoronicotinic acid

Chemical Property of 5-fluoro-6-bromonicotinc acid

Chemical Property:

• Vapor Pressure: 0.000138mmHg at 25°C
• Melting Point: 191-196°C
• Boiling Point: 319.8°C at 760 mmHg
• Flash Point: 147.2°C
• PSA: 50.19000
• Density: 1.903g/cm³
• LogP: 1.68140

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Bromo-5-fluoronicotinic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• General Description: 5-Fluoro-6-bromonicotinic acid (also known as 6-bromo-5-fluoronicotinic acid) is a dihalonicotinic acid derivative synthesized through the oxidation of corresponding dihalo-3-picoline precursors, as described in the study. It is part of a series of compounds prepared to explore their structural and spectral properties, though the abstract does not provide further specific details about its applications or reactivity.

Technology Process of 5-fluoro-6-bromonicotinc acid

There total 1 articles about 5-fluoro-6-bromonicotinc acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 6-bromo-5-fluoropyridine-3-carboxylic acid (38186-87-7)

Guidance literature:

/BRN= 386414/, KMnO4;

DOI:10.1021/je60055a035

Reference yield:

2-(4,4-difluorocyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1227068-84-9) + 6-bromo-5-fluoropyridine-3-carboxylic acid (38186-87-7) → 6-(4,4-Difluorocyclohex-1-en-1-yl)-5-fluoronicotinic acid

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; at 90 ℃; for 8h; Inert atmosphere;

Refernces

Some 2,5- and 5,6-Dihalonicotinic Acids and Their Precursors. II" and "Bithiazole Derivatives

10.1021/je60055a035

The study focuses on the synthesis and spectral data of certain chemical compounds. The first part of the study, conducted by Frank L. Setliff and Gary O. Rankin, involves the preparation of 2-chloro- and 2-bromo-5-fluoronicotinic acid and 6-chloro- and 6-bromo-5-fluoronicotinic acid through the oxidation of corresponding dihalo-3-picolines. The dihalo-3-picolines serve as precursors for the acids. The study also includes the preparation of amines Ie and If through dissolving-metal reduction, and the subsequent diazotization and thermal decomposition to produce other compounds. The second part of the study, conducted by George Y. Sarkis and Subhi Al-Azawe, involves the synthesis of nine bithiazole derivatives by the interaction of rubeanic acid with various α-haloketones. The study provides experimental and spectral data for these compounds. The chemicals involved, such as nicotinic acid, dihalo-3-picolines, rubeanic acid, and α-haloketones, play crucial roles in the synthesis processes and the formation of the target compounds.

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